Fernanda E.
- Country
- Portugal
- Department
- Servico de Oncologia
Research Overview
- Comparison of Sotorasib Plus Combination Therapy Versus Pembrolizumab Plus Combination Therapy in PD-L1 Negative KRAS p.G12C Positive Advanced Non-Squamous NSCLC
- Phase II Dose Selection Study of Intravenous BI 764532 in Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer and Neuroendocrine Carcinomas
- Phase 3 Study of BAY 2927088 vs. Standard of Care in HER2-Mutant Advanced NSCLC
Data & Insights
Has run more than one trial at 167 of 412 partner sites.
Specializations
Thoracic and Gastrointestinal Oncology
Maria Fernanda Estevinho is involved in clinical research across non-small cell lung cancer, small cell lung cancer, and other neuroendocrine neoplasms, with additional activity in gastroesophageal adenocarcinoma, gastric cancer, and head and neck squamous cell carcinoma.
- Advanced and metastatic lung cancer
- Neuroendocrine and DLL3-targeted solid tumours
- Gastric, gastroesophageal, and head and neck malignancies
Her oncology portfolio also includes studies in HER2-positive and FGFR2b-expressing tumour settings, reflecting a strong focus on biomarker-defined cancer care.
Breast Cancer and Targeted Endocrine Therapy
Her research interests extend to multiple breast cancer settings, including early breast cancer, locally advanced disease, and metastatic hormone receptor-positive and HER2-negative disease.
- HER2-positive and HER2-negative breast cancer
- Endocrine-based treatment strategies
- Antibody-drug conjugate and combination approaches
Her trial activity also covers recurrence prevention and treatment sequencing in high-risk breast cancer populations.
Cardiovascular and Metabolic Disease
Her clinical research landscape includes atherosclerotic cardiovascular disease, atrial fibrillation, heart failure, hypertension, obesity, and type 2 diabetes, with a strong emphasis on prevention and risk reduction.
- Stroke prevention and systemic embolism
- Lipid-lowering and cardiovascular risk reduction
- Metabolic disease and cardiometabolic complications
She is also involved in studies addressing diabetic retinopathy and non-alcoholic steatohepatitis, linking metabolic disease with end-organ outcomes.
Neurology, Cognition, and Seizure Disorders
Her research activity spans Alzheimer’s disease, mild cognitive impairment, dementia-related agitation, psychosis, multiple sclerosis, epilepsy, and migraine.
- Cognitive decline and dementia-related symptoms
- Relapsing and progressive demyelinating disease
- Focal seizures, generalized tonic-clonic seizures, and migraine prevention
Her portfolio includes work in inflammatory neuropathy and stroke-related neurological impairment, broadening her involvement in central and peripheral nervous system disorders.
Respiratory, Immunologic, and Fibrotic Disorders
Maria Fernanda Estevinho is also active in studies of asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, and progressive fibrosing interstitial lung disease.
- Eosinophilic and severe asthma
- Chronic obstructive and fibrosing lung disease
- Immune-mediated urticaria and inflammatory disease
Her therapeutic interests further include chronic spontaneous urticaria, atopic dermatitis, and chronic inflammatory demyelinating polyneuropathy, underscoring a broad commitment to immune-driven disease areas.
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