Hospital CUF Porto S.A.

At Hospital CUF Porto S.A., the clinical research portfolio is strongly centered on cancer care, with many studies focused on non-small cell lung cancer, small cell lung cancer, and other advanced solid tumors. These trials are designed to test new treatment approaches, compare them with current standards, and improve outcomes for patients with difficult-to-treat cancers.

• Studies in advanced lung cancer, especially NSCLC and SCLC, evaluating new immunotherapy and targeted treatment strategies
• Research in HER2, KRAS G12C, ALK-positive, and c-Met cancers, aimed at more precise treatment selection
• Trials in breast cancer exploring recurrence prevention and endocrine-based treatment options
• Work on neuroendocrine tumors and other advanced solid tumors to assess antitumor activity and survival benefits

Overall, the site’s Oncology Department is contributing to a broad mix of studies that seek to improve survival, disease control, and treatment tolerability across several cancer types.

The site also supports research in respiratory diseases and allergic conditions, including asthma and allergic rhinitis. These studies are generally aimed at improving symptom control, lung function, and day-to-day quality of life for people living with chronic airway and immune-related conditions.

• Asthma studies assessing better control of breathing symptoms and lung performance
• Allergic rhinitis and rhinoconjunctivitis research focused on easing allergy-related discomfort
• Trials involving house dust mite allergy to evaluate new ways of reducing immune-triggered symptoms

These projects reflect a smaller but important part of the research activity at Hospital CUF Porto S.A., with an emphasis on improving everyday respiratory care.

Another active area is metabolic health, with studies on obesity and type 2 diabetes in both children and adults. The main goal is to evaluate treatments that may support healthier weight management and reduce long-term health risks linked to excess body weight.

• Obesity research in children and adolescents, including support for weight management
• Studies in obesity and type 2 diabetes looking at broader metabolic benefits
• Trials in overweight populations assessing whether new therapies can help sustain weight loss

These trials broaden the site’s research profile beyond cancer, showing interest in conditions that affect long-term health across different age groups.

The research portfolio also includes studies relevant to women’s health and mental health. In women with hormone-receptor positive breast cancer, some trials focus on managing treatment-related symptoms, while in psychiatry the site is involved in research on major depressive disorder, especially when sleep problems are part of the condition.

• Vasomotor symptoms linked to endocrine therapy in women at risk for or living with hormone-receptor positive breast cancer
• Major depressive disorder with insomnia symptoms, studying symptom relief and relapse prevention

These studies aim to improve supportive care and daily functioning, complementing the site’s broader disease-focused research.

Across several tumor types, the site is participating in trials that compare new combinations against established treatments, with a strong focus on efficacy, overall survival, and progression-free survival. This includes work in advanced non-small cell lung cancer, metastatic disease, and solid tumors where new targeted or immune-based therapies may offer better control of disease.

• Comparative studies testing whether new cancer therapies perform better than current standards of care
• Research in advanced or metastatic disease to help improve survival outcomes
• Trials exploring precision oncology approaches for biomarker-defined patient groups

This broad oncology activity highlights the site’s role in evaluating innovative treatment options for patients with complex and advanced cancers.