Manuel B.
- Country
- Portugal
- Department
- Serviço de Oncologia Pediátrica
Research Overview
- Interfant-21: International collaborative treatment protocol for infants under one year with KMT2A-rearranged acute lymphoblastic leukemia or mixed phenotype acute leukemia
- Evaluation of Quizartinib in Combination with Chemotherapy for Pediatric FLT3-ITD Positive, NPM1 Wild-Type Acute Myeloid Leukemia
- Evaluation of Gemtuzumab Ozogamicin and Drug Combination in Pediatric Acute Myeloid Leukemia: A NOPHO-DB-SHIP Consortium Study
Data & Insights
Has run more than one trial at 106 of 217 partner sites.
Specializations
Pediatric Leukemia Research
The investigator specializes in treating acute myeloid leukemia (AML) in children and adolescents, with particular expertise in managing cases involving FLT3-ITD mutations and NPM1 wild-type variants.
- Novel therapeutic approaches for AML
- Molecular mutation analysis
- Pediatric chemotherapy protocols
Their work extends to studying targeted therapies such as quizartinib for specific genetic mutations in pediatric AML patients.
ALL Treatment Innovation
The investigator focuses on advancing treatment protocols for acute lymphoblastic leukemia (ALL), with special attention to high-risk relapsed cases and infant ALL patients under one year of age.
- Infant leukemia protocols
- KMT2A-rearranged ALL
- Relapse treatment strategies
Their research includes evaluating novel therapeutic approaches including immunotherapy and proteasome inhibitors in ALL treatment.
Age-Specific Leukemia Care
The investigator develops comprehensive treatment approaches for leukemia patients aged 0-45 years, focusing on age-adapted protocols and survival improvement strategies.
- Age-specific treatment protocols
- Quality of survival assessment
- Long-term outcome studies
Their work encompasses both standard risk and high-risk patient populations across different age groups.
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