Francisco P.
- Country
- Portugal
- Department
- Gastroenterology
Research Overview
- Evaluation of Transmural Healing as a Treatment Target in Moderately to Severely Active Crohn's Disease Using Upadacitinib, Risankizumab, and Ustekinumab
- Efficacy and Safety of Risankizumab as Maintenance Therapy in Moderately to Severely Active Ulcerative Colitis: A Randomized, Double-Blind, Placebo-Controlled Study
- Open-Label Extension Study Assessing Long-Term Safety of Etrasimod Arginine in Patients with Moderately to Severely Active Ulcerative Colitis
Data & Insights
Has run more than one trial at 99 of 264 partner sites.
Specializations
Gastroenterology and Inflammatory Bowel Disease
Clinical research activity includes treatment approaches for Crohn's disease and other chronic inflammatory conditions of the digestive tract, with attention to biologic and targeted immune therapies.
- Crohn's disease
- Moderately to severely active inflammatory bowel disease
- Endoscopic outcomes
- Intestinal inflammation
Interest also extends to advanced treatment strategies for gastrointestinal immune-mediated disease within the Department of Gastroenterology at Centro Hospitalar E Universitario De Coimbra E.P.E.
Upper Gastrointestinal and Hepatobiliary Oncology
The investigator is involved in therapeutic research for malignancies of the upper digestive tract and biliary system, including recurrent, metastatic, and unresectable disease settings.
- Gastroesophageal adenocarcinoma
- Esophageal or gastric cancer
- Biliary tract cancer
- Metastatic gastric cancer
Research activity in this area reflects a focus on HER2-positive and PD-L1-associated gastrointestinal cancers.
Cardiovascular and Thromboembolic Disease
Clinical trial involvement includes prevention and treatment strategies for atrial fibrillation, stroke, hypertension, and broader atherosclerotic cardiovascular disease.
- Atrial fibrillation
- Acute ischemic stroke
- Established cardiovascular disease
- Heart failure with preserved or mildly reduced ejection fraction
Additional involvement includes studies of cardiometabolic risk reduction and long-term management of cardiovascular disease.
Neurology and Neurodegenerative Disorders
The investigator contributes to research in multiple sclerosis, Alzheimer's disease, frontotemporal dementia, and seizure disorders, spanning both chronic and progressive neurological conditions.
- Relapsing remitting multiple sclerosis
- Progressive forms of multiple sclerosis
- Epilepsy
- Early Alzheimer's disease
Research interests also include developmental and epileptic encephalopathies and migraine.
Respiratory, Hematologic, and Immune-Mediated Disease
Trial activity covers chronic airway disease, blood disorders, and systemic immune conditions, with participation in studies addressing both adult and pediatric populations.
- Chronic obstructive pulmonary disease
- Severe uncontrolled asthma
- Acute myeloid leukemia
- Psoriatic arthritis
Other areas include chronic spontaneous urticaria, primary immunologic disorders, and pulmonary arterial hypertension.
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