Clinical Research
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ZonMW

Address
Laan Van Nieuw-Oost-Indie 334

Sponsor Overview

assignment
1
sponsored trial
science
0
molecules
location_city
21
research centres
public
1
country
person_search
20
investigators

Specializations

Autoimmune hypothyroidism and thyroid hormone replacement

Research activity is centered on hypothyroidism in people with ongoing symptoms despite standard levothyroxine treatment, with a focus on thyroid hormone balance and persistent fatigue.

  • Levothyroxine monotherapy
  • LT4/LT3 combination therapy
  • Autoimmune thyroid disease

Clinical interest extends to symptom burden in treated thyroid disease, particularly ongoing tiredness and related quality of life concerns.

Triiodothyronine and combination endocrine therapy

The funded research landscape includes the role of triiodothyronine within thyroid replacement strategies, with attention to how combined T4/T3 therapy relates to residual complaints in thyroid dysfunction.

  • Triiodothyronine
  • T4/T3 replacement
  • Persistent symptoms

This area reflects a therapeutic focus on symptom control in patients whose thyroid hormone therapy leaves unresolved tiredness.

Patient-reported outcomes and quality of life

Another clear area of interest is the measurement of tiredness, persistent complaints, and quality of life in individuals living with chronic thyroid-related symptoms.

  • Fatigue assessment
  • Quality of life
  • Persistent complaints

The clinical emphasis is on symptom experience in everyday life, especially among patients who remain symptomatic under standard replacement treatment.

Genetic variation in thyroid response

The research portfolio also includes interest in genetic factors that may influence response to thyroid therapy, particularly variation in DIO2 and MCT10 in relation to treatment-related symptom improvement.

  • DIO2 genetic variation
  • MCT10 genetic variation
  • Individual treatment response

This supports a focus on biologic differences that may shape outcomes in thyroid hormone replacement.

Sponsored Trials

Trial Name Country Status
Evaluation of Levothyroxine and Liothyronine Combination Therapy Versus Levothyroxine Monotherapy in Autoimmune Hypothyroidism with Persistent FatigueThe Netherlands The NetherlandsRecruiting

Data & Insights

science
Molecule Portfolio
Compounds under investigation
0
Exclusive Molecules
out of 0 total (0% not shared with other sponsors)

This sponsor works with 0 molecules, of which 0 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
0%
Return partnership rate
0 of 21 sites collaborated multiple times

This sponsor has worked with 21 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Hormonal diseases1 trial
    89 other sponsors

Partnered Research Centres

21 centres
location_city
assignment38
Admiraal De Ruyter Ziekenhuis B.V.
Address
'S-Gravenpolderseweg 114, 4462 RA Goes
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location_city
assignment126
Albert Schweitzer Ziekenhuis
Address
Albert Schweitzerplaats 25, 3318 AT Dordrecht
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location_city
assignment192
Amphia Hospital
Address
Molengracht 21, 4818 CK Breda
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location_city
assignment155
Amsterdam UMC
Address
Meibergdreef 9, 1105 AZ Amsterdam
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location_city
assignment711
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Address
Dr. Molewaterplein 40, 3015 GD Rotterdam
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location_city
assignment41
Flevoziekenhuis Stichting
Address
Hospitaalweg 1, 1315 RA Almere Stad
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