X4 Pharmaceuticals Inc.
- Address
- 61 North Beacon Street
Sponsor Overview
Specializations
Neutropenia and chronic neutropenic disorders
X4 Pharmaceuticals Inc. focuses on clinical research in congenital and acquired forms of primary autoimmune and idiopathic chronic neutropenia, with attention to patients affected by recurrent and serious infections.
- Absolute neutrophil count recovery
- Infection rate reduction
- Chronic neutropenic disorders
The sponsor’s work in this area is centered on restoring circulating neutrophil levels and addressing the clinical burden associated with persistent neutropenia.
WHIM syndrome
The company also funds research in Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome, a rare immunodeficiency disorder marked by low neutrophil counts and recurrent infections.
- Circulating neutrophils
- Hypogammaglobulinemia
- Recurrent infections
Clinical interest in this condition includes improvement of hematologic and immune-related features that contribute to disease severity.
Immunology and host defense
X4 Pharmaceuticals Inc. maintains a therapeutic focus on disorders of immune function where impaired innate defense and reduced neutrophil availability increase susceptibility to infection.
- Immune dysregulation
- Susceptibility to infection
- Myelokathexis
This research area reflects interest in conditions where immune cell trafficking and neutrophil mobilization are central to clinical management.
Sponsored Trials
| Trial Name | Country | Status |
|---|---|---|
| Phase 3 Randomized Double-Blind Placebo-Controlled Study of Mavorixafor in Chronic Neutropenia with Recurrent or Serious Infections |  Belgium Czechia France Germany Greece Hungary Ireland Italy Poland Portugal Romania Spain | Recruiting |
| Phase 3 Randomized Double-Blind Study of Mavorixafor Versus Placebo in WHIM Syndrome Patients with Open-Label Extension |  Denmark France Italy Spain The Netherlands | Not Recruiting |
Data & Insights
This sponsor works with 1 molecule, of which 1 is not being studied by other sponsors.
This sponsor has worked with 46 sites across their trial portfolio.
Therapeutic Focus
- 1.Congenital, Hereditary, and Neonatal Diseases and Abnormalities1 trial165 other sponsors
- 2.Immune System Diseases1 trial322 other sponsors
- 3.Immune system processes1 trial65 other sponsors
Partnered Research Centres
46 centres- Address
- Kanellopoulou Avenue 3, 115 25 Athens
- Address
- De Boelelaan 1117, 1081 HV Amsterdam
- Address
- 26 Avenue Du Docteur Arnold Netter, 75012 Paris
- Address
- Via Cherasco 15, 10126 Turin
- Address
- Via Filippo Corridoni 11, 60123 Ancona
- Address
- 165 Chemin Du Grand Revoyet, 69310 Pierre Benite
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