Viiv Healthcare UK Limited

Address
980 Great West Road

Sponsor Overview

assignment
12
sponsored trials
science
12
molecules
location_city
133
research centres
public
14
countries
person_search
172
investigators

Specializations

HIV-1 Treatment in Antiretroviral-Naïve Adults

Clinical research includes oral and long-acting antiretroviral therapy options for adults newly diagnosed with HIV, with attention to viral suppression, treatment initiation, and regimen selection in people who have not previously received therapy.

  • Oral once-daily treatment regimens
  • Long-acting injectable ART
  • Viral suppression in treatment-naïve adults

Studies also examine comparative effectiveness between simplified dual-drug and standard multi-drug approaches in initial HIV-1 management.

Long-Acting and Switch-Based Maintenance Therapy

Research activity extends to maintaining virologic suppression after switching from established oral regimens to long-acting combinations, including injectable approaches for adults already living with controlled HIV infection.

  • Switch strategies after suppression
  • Two-monthly injectable combinations
  • Durability of treatment response

This area includes assessment of treatment choice and preference in adults considering oral versus injectable maintenance options.

Heavily Treatment-Experienced and Drug-Resistant HIV

The sponsor supports studies in adults with limited treatment options due to multidrug-resistant HIV-1 or prior antiretroviral exposure, including settings where current regimens are failing or no longer fully effective.

  • Drug-resistant HIV-1
  • Heavily treatment-experienced populations
  • Salvage and rescue treatment strategies

Research in this domain focuses on restoring antiviral control in people with complex treatment histories.

Novel Antiviral Agents and Regimen Innovation

Clinical work includes evaluation of new HIV therapies such as attachment inhibitors, capsid-targeting agents, and other oral compounds designed to expand treatment choices for both untreated and treatment-experienced adults.

  • Attachment inhibitor-based regimens
  • Capsid-directed antiviral candidates
  • Oral regimen development

These studies are directed toward improving antiviral activity and broadening options for HIV-1 management.

Reservoir and Immune-Based HIV Research

Additional research interest includes the viral reservoir and the use of broadly neutralizing antibodies alongside integrase inhibitor-based therapy in adults living with HIV.

  • Viral reservoir modulation
  • Broadly neutralizing antibodies
  • Combination approaches with integrase-based therapy

This area reflects interest in deeper virologic control beyond routine suppression.

Sponsored Trials

Trial Name Country Status
A Phase 2b Randomized, Open-Label Active Controlled Study Evaluating the Safety and Efficacy of oral VH4524184 Coadministered with Emtricitabine and Tenofovir Alafenamide in Treatment Naïve Viremic Persons with HIV-1.( INNOVATE Study)Belgium BelgiumFrance FranceGermany GermanyItaly ItalyPoland PolandPortugal PortugalSpain SpainRecruiting
A Phase 3b Study Comparing Dolutegravir/Lamivudine to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Antiretroviral-Naive Adults with HIVBelgium BelgiumDenmark DenmarkFrance FranceGermany GermanyGreece GreeceIreland IrelandItaly ItalyPoland PolandPortugal PortugalSpain SpainSweden SwedenNot Recruiting
Evaluation of Antiviral Efficacy and Safety of GSK4004280 and GSK4011499 in Treatment-Naïve Adults with HIV-1 InfectionFrance FranceGermany GermanyItaly ItalySpain SpainNot Recruiting
Evaluation of Antiviral Efficacy, Safety, and Pharmacokinetics of VH4524184 in Treatment-Naïve Adults with HIV-1: A Randomized, Double-Blind, Placebo-Controlled StudyItaly ItalySpain SpainNot Recruiting
Evaluation of Dolutegravir/Lamivudine and Cabotegravir/Rilpivirine for Virologic Suppression in Antiretroviral-Naive HIV-1 Infected AdultsFrance FranceGermany GermanyItaly ItalySpain SpainNot Recruiting
Evaluation of Efficacy, Safety, and Tolerability of Switching from Bictegravir/Emtricitabine/Tenofovir Alafenamide to Dolutegravir/Lamivudine in Virologically Suppressed HIV Patients Aged 50+Austria AustriaBelgium BelgiumFrance FranceGermany GermanyItaly ItalyPortugal PortugalSpain SpainThe Netherlands The NetherlandsNot Recruiting
Evaluation of the Antiviral Efficacy and Safety of GSK3739937 in Treatment-Naïve Adults with HIV-1 Infection: A Randomized, Double-Blind, Placebo-Controlled StudyGreece GreeceItaly ItalyPoland PolandSpain SpainNot Recruiting
Evaluation of the Impact of a Broadly Neutralizing Antibody and Attachment Inhibitor on Viral Reservoirs in HIV Patients on Integrase Inhibitor-Based Antiretroviral TherapyBelgium BelgiumDenmark DenmarkSpain SpainThe Netherlands The NetherlandsNot Recruiting
Mass Balance and Absolute Oral Bioavailability of [14C]VH4524184 in Adults With Human Immunodeficiency Virus (HIV)The Netherlands The NetherlandsRecruiting
Phase 3 Randomized Non‑Inferior Trial of Ultra‑Long‑Acting Cabotegravir + Rilpivirine vs Long‑Acting Formulations in Adults/Adolescents with Virologically Suppressed HIVSpain SpainRecruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
5
Exclusive Molecules
out of 12 total (42% not shared with other sponsors)

This sponsor works with 12 molecules, of which 5 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
50%
Return partnership rate
67 of 133 sites collaborated multiple times

This sponsor has worked with 133 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Virus Diseases10 trials
    182 other sponsors
  • 2.
    Immune System Diseases2 trials
    322 other sponsors

Partnered Research Centres

133 centres
location_city
assignment352
Aarhus University Hospital
Address
Palle Juul-Jensens Boulevard 99, 8200 Aarhus
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location_city
assignment63
Althaia Xarxa Assistencial Universitaria De Manresa Fundacio Privada
Address
Carrer Del Doctor Joan Soler 1-3, 08243 Manresa
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location_city
assignment155
Amsterdam UMC
Address
Meibergdreef 9, 1105 AZ Amsterdam
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location_city
assignment86
Area De Salud De Burgos Y Soria
Address
Avenida De Las Islas Baleares 3, 09006 Burgos
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location_city
assignment72
Assistance Publique Hopitaux De Paris
Address
46 Rue Henri Huchard, 75877 Paris
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location_city
assignment478
Assistance Publique Hopitaux De Paris
Address
Num Voie 47 A 83, 47 Boulevard De L Hopital, 75013 Paris
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