VectivBio AG

Address: Aeschenvorstadt 36

Sponsor Overview

assignment

Specializations

Gastrointestinal transplant complications

Research activity includes acute graft versus host disease, with a focus on steroid-refractory gastrointestinal aGVHD affecting the lower digestive tract.

Immune-mediated intestinal injury
Gastrointestinal inflammation
Post-transplant complications

The sponsor’s studies in this area are centered on gastrointestinal symptoms and clinical safety in patients with severe transplant-related bowel involvement.

Short bowel syndrome

Another key area is short bowel syndrome, including short bowel syndrome with intestinal failure, where the clinical focus is on digestive support and long-term management.

Intestinal failure
Nutritional absorption
Chronic gastrointestinal care

These trials address persistent malabsorption and the ongoing clinical burden associated with reduced bowel length.

Healthy volunteer pharmacology

The sponsor also supports studies in healthy adults to examine the bioavailability and comparative formulation performance of investigational therapy.

Subcutaneous administration
Pharmacokinetics
Formulation comparison

This area reflects interest in how the therapy is absorbed and handled in the body under controlled clinical conditions.

Peptide-based gastrointestinal therapy

Across its portfolio, the sponsor is focused on apraglutide, a GLP-2 analog studied for disorders involving impaired intestinal function and bowel recovery.

Intestinal repair
Digestive tract support
Therapeutic peptide development

The research spans both rare gastrointestinal diseases and supportive treatment strategies for patients with significant bowel dysfunction.

Trial Name	Country	Status
Evaluation of Apraglutide Efficacy and Safety in Steroid-Refractory Gastrointestinal Acute Graft-Versus-Host Disease: A Randomized, Single-Blind Trial	Germany	Not Recruiting
Evaluation of Long-term Safety and Tolerability of Apraglutide in Patients with Short Bowel Syndrome-Intestinal Failure	Belgium Czechia Denmark France Germany Hungary Italy Norway Poland Spain Sweden	Not Recruiting
Evaluation of the Relative Bioavailability of Apraglutide Compared to Reference Formulation in Healthy Subjects: A Randomized, Open-label, Cross-Over Study	The Netherlands	Not Recruiting