Universitair Medisch Centrum Utrecht

Address
Heidelberglaan 100

Sponsor Overview

assignment
51
sponsored trials
science
139
molecules
location_city
275
research centres
public
19
countries
person_search
406
investigators

Specializations

Oncology and Hematologic Malignancies

Universitair Medisch Centrum Utrecht is active in studies across solid tumors and blood cancers, with interest in colorectal cancer, head and neck squamous cell carcinoma, endometrial cancer, liver metastases, acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma. Its trial portfolio also includes rare and difficult-to-treat cancers such as parotid gland carcinoma, diffuse midline glioma, and pheochromocytoma.

  • metastatic colorectal cancer
  • oral cancer
  • colorectal liver metastases
  • H3K27-altered pontine diffuse midline glioma
  • acute myeloid leukemia

Research interests extend to sentinel lymph node mapping, imaging-guided treatment selection, and locoregional approaches for advanced malignancy.

Immune-Mediated, Rheumatologic, and Rare Inflammatory Disease

The sponsor supports trials in systemic sclerosis, idiopathic inflammatory myopathies, IgG4-related disease, primary Sjögren's syndrome, psoriatic arthritis, Behçet's disease, and Still's disease. Additional work includes immune deficiency and antibody-associated disorders such as common variable immunodeficiency, IgA deficiency, and IgM monoclonal gammopathy of unknown significance with anti-MAG polyneuropathy.

  • systemic sclerosis
  • primary Sjögren's syndrome
  • idiopathic inflammatory myopathies
  • psoriatic arthritis
  • immune deficiency disorders

Its portfolio also covers diffuse cutaneous systemic sclerosis, pseudoxanthoma elasticum, and other rare immune-mediated conditions with vascular, musculoskeletal, or neurologic involvement.

Neurology, Neurodevelopment, and Brain Injury

Clinical research includes refractory epilepsy, Fahr's disease, Fahr's syndrome, perinatal arterial ischemic stroke, and neonatal brain injury associated with critical congenital heart disease. The sponsor also funds studies in diffuse midline glioma and conditions involving cognitive and neurologic decline.

  • refractory epilepsy
  • perinatal arterial ischemic stroke
  • neonatal brain injury
  • Fahr's disease
  • diffuse midline glioma

Work in this area also spans brain protection in newborns, neurologic outcomes after stroke, and disorders affecting cognition, movement, and seizure control.

Cardiovascular, Vascular, and Metabolic Disorders

Trial activity includes peripheral arterial disease, carotid artery stenosis, arterial calcification, and vascular complications of systemic sclerosis. The sponsor also studies type 2 diabetes mellitus, congenital haemophilia A, and atherosclerotic disease with interest in bleeding prevention, vascular imaging, and endothelial injury.

  • peripheral arterial disease
  • carotid artery stenosis
  • type 2 diabetes mellitus
  • congenital haemophilia A
  • arterial calcification

Its research also addresses myocardial and vascular protection, limb ischemia, and complications linked to chronic metabolic and circulatory disease.

Infectious, Respiratory, Psychiatric, and Reproductive Health

The sponsor funds studies in COVID-19, post-acute sequelae of SARS-CoV-2 infection, monkeypox, Staphylococcus aureus bacteremia, and respiratory tract infection. It also supports research in schizophrenia, major depressive disorder, bipolar depression, anxiety disorders, and post-traumatic stress disorder, alongside reproductive and fertility care such as unexplained subfertility and intra-uterine insemination.

  • COVID-19
  • post-acute sequelae of SARS-CoV-2 infection
  • schizophrenia
  • major depressive disorder
  • unexplained subfertility

Additional interests include acute respiratory infections, viral clearance, mood disorders, and treatment-resistant psychiatric illness.

Sponsored Trials

Trial Name Country Status
A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Safety of Dirocaftor/Posenacaftor/Nesolicaftor in Subjects with Cystic Fibrosis Aged 18Years or Older (CHOICES)Belgium BelgiumCzechia CzechiaDenmark DenmarkGermany GermanyItaly ItalyPortugal PortugalSpain SpainSweden SwedenThe Netherlands The NetherlandsNot Yet Recruiting
A Phase IIb, Multicentre, Randomised, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Safety of Dirocaftor/Posenacaftor/Nesolicaftor in Subjects with Cystic Fibrosis Aged 18 Years or Older (CHOICES)Belgium BelgiumCzechia CzechiaFrance FranceGermany GermanyItaly ItalyPortugal PortugalSpain SpainSweden SwedenThe Netherlands The NetherlandsNot Recruiting
A randomised, controlled trial to investigate the effect of a four/six week intensified pharmacological treatment for schizophrenia, major depressive disorder and bipolar depression compared to treatment as usual in subjects who had a first-time treatment failure on their first-line treatment.Austria AustriaGermany GermanyItaly ItalySpain SpainNot Yet Recruiting
Adaptive Platform Trial Assessing Minocycline, Colchicine, and Metformin on Physical Health‑Related Quality of Life in Post‑Acute Sequelae of SARS‑CoV‑2 Infection (PASC)The Netherlands The NetherlandsRecruiting
Biomarker-Guided Anakinra Tapering Strategy in Pediatric Systemic Juvenile Idiopathic Arthritis: A Randomized Controlled TrialThe Netherlands The NetherlandsNot Yet Recruiting
Comparative Efficacy of Autologous Hematopoietic Stem Cell Transplantation Versus Immunosuppressive Therapy in Early Diffuse Cutaneous Systemic SclerosisItaly ItalySweden SwedenThe Netherlands The NetherlandsRecruiting
Comparison of Weekly Low-Dose Versus Three-Weekly High-Dose Cisplatin in Chemoradiation for Sarcopenic Patients with Locally Advanced Head and Neck Squamous Cell CarcinomaThe Netherlands The NetherlandsNot Recruiting
Efficacy of Add-On Cannabidiol and Dronabinol in Pediatric Refractory Epilepsy: A Randomized, Double-Blind, Placebo-Controlled TrialThe Netherlands The NetherlandsRecruiting
European Clinical Research Alliance on Infectious Diseases – primary care adaptive platform trial for pandemics and epidemics (ECRAID-Prime)Belgium BelgiumFrance FranceGermany GermanyIreland IrelandPoland PolandSpain SpainNot Recruiting
European Randomised Clinical Trial on mPOX Infection (EPOXI)Belgium BelgiumFrance FranceGermany GermanyItaly ItalyNorway NorwayPortugal PortugalSpain SpainThe Netherlands The NetherlandsNot Recruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
21
Exclusive Molecules
out of 139 total (15% not shared with other sponsors)

This sponsor works with 139 molecules, of which 21 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
29%
Return partnership rate
79 of 275 sites collaborated multiple times

This sponsor has worked with 275 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Neoplasms10 trials
    853 other sponsors
  • 2.
    Immune System Diseases8 trials
    322 other sponsors
  • 3.
    Mental Disorders5 trials
    150 other sponsors
  • 4.
    Nervous System Diseases5 trials
    449 other sponsors
  • 5.
    Digestive System Diseases4 trials
    280 other sponsors
  • 6.
    Virus Diseases4 trials
    182 other sponsors
  • 7.
    Cardiovascular Diseases3 trials
    359 other sponsors
  • 8.
    Hemic and Lymphatic Diseases3 trials
    249 other sponsors
  • 9.
    Musculoskeletal Diseases3 trials
    238 other sponsors
  • 10.
    Respiratory Tract Diseases3 trials
    277 other sponsors
  • 11.
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities2 trials
    165 other sponsors
  • 12.
    Diagnosis2 trials
    83 other sponsors
  • 13.
    Female Urogenital Diseases and Pregnancy Complications2 trials
    142 other sponsors
  • 14.
    Investigative Techniques2 trials
    35 other sponsors
  • 15.
    Reproductive and Urinary Physiological Phenomena2 trials
    33 other sponsors
  • 16.
    Skin and Connective Tissue Diseases2 trials
    247 other sponsors
  • 17.
    Bacterial Infections and Mycoses1 trial
    180 other sponsors
  • 18.
    Behavior and Behavior Mechanisms1 trial
    38 other sponsors
  • 19.
    Eye Diseases1 trial
    138 other sponsors
  • 20.
    Hormonal diseases1 trial
    89 other sponsors
  • 21.
    Nutritional and Metabolic Diseases1 trial
    211 other sponsors
  • 22.
    Surgical Procedures, Operative1 trial
    58 other sponsors

Partnered Research Centres

275 centres
location_city
assignment61
Academisch Ziekenhuis Leiden
Address
Albinusdreef 2, 2333 ZA Leiden
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location_city
assignment1
Akademicka Praktyka Medycyny Rodzinnej Bielska Chlabicz Czarnowski Oltarzewska Sawicka-Powierza sp.p.
Address
Ul. Mazowiecka 33, 15-301 Bialystok
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location_city
assignment192
Amphia Hospital
Address
Molengracht 21, 4818 CK Breda
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location_city
assignment680
Amsterdam UMC
Address
De Boelelaan 1117, 1081 HV Amsterdam
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location_city
assignment155
Amsterdam UMC
Address
Meibergdreef 9, 1105 AZ Amsterdam
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location_city
assignment9
Area Sanitaria Da Coruna E Cee
Address
Lugar Jubias De Arriba Num 84, 15006 A Coruna Galicia
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