Clinical Research

Travere Therapeutics Inc.

Address
3611 Valley Centre Drive Suite 300

Sponsor Overview

assignment
5
sponsored trials
science
3
molecules
location_city
103
research centres
public
15
countries
person_search
113
investigators

Specializations

Kidney Disease and Proteinuria

Travere Therapeutics Inc. supports research in proteinuric glomerular diseases, with emphasis on focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), IgA nephropathy (IgAN), IgA vasculitis (IgAV), and Alport syndrome. Its studies focus on renal protection, reduction of proteinuria, and preservation of kidney function.

  • FSGS
  • IgA nephropathy
  • Alport syndrome

Research activity in this area reflects a strong therapeutic interest in chronic glomerular disease and related kidney injury.

Rare Renal Disorders in Pediatric and Adult Populations

The sponsor funds clinical research across both pediatric and adult patients with selected kidney diseases, including conditions marked by persistent proteinuria and progressive loss of renal function. These studies address treatment needs in uncommon nephrology populations.

  • Pediatric kidney disease
  • Renal function preservation
  • Proteinuria control

This area includes ongoing interest in renal disorders where long-term management is central to clinical care.

Classical Homocystinuria

Travere Therapeutics Inc. also funds research in classical homocystinuria (HCU), a rare inherited metabolic disorder associated with elevated homocysteine and methionine levels. The therapeutic focus includes biochemical control and treatment options for patients receiving standard care.

  • Homocystinuria
  • Homocysteine metabolism
  • Inherited metabolic disease

Clinical activity in this field centers on rare disease management and metabolic correction.

Sponsored Trials

Trial Name Country Status
Efficacy and Safety Evaluation of Sparsentan in Patients with Immunoglobulin A Nephropathy: A Randomized, Double-Blind, Active-Controlled StudyBelgium BelgiumCroatia CroatiaCzechia CzechiaEstonia EstoniaFrance FranceGermany GermanyItaly ItalyLithuania LithuaniaPoland PolandPortugal PortugalSpain SpainNot Recruiting
Efficacy and Safety of Pegtibatinase Added to Standard of Care in Participants with Classical Homocystinuria Due to Cystathionine Beta Synthase DeficiencyBelgium BelgiumFrance FranceGermany GermanyIreland IrelandItaly ItalyPoland PolandPortugal PortugalSpain SpainNot Yet Recruiting
Evaluation of Sparsentan in Pediatric Patients with Proteinuric Glomerular Diseases: A Phase 2, Open-Label, Single-Arm Cohort StudyGermany GermanyItaly ItalyPoland PolandSpain SpainSweden SwedenThe Netherlands The NetherlandsRecruiting
Evaluation of Sparsentan Versus Irbesartan on Renal Outcomes in Patients with Primary Focal Segmental Glomerulosclerosis (FSGS)Belgium BelgiumCroatia CroatiaCzechia CzechiaDenmark DenmarkEstonia EstoniaFrance FranceGermany GermanyItaly ItalyPoland PolandPortugal PortugalSpain SpainSweden SwedenNot Recruiting
Phase 1/2 Study of Subcutaneous Pegtibatinase (TVT‑058) for Safety, Tolerability, PK/PD and Clinical Outcomes in Patients with Classical Homocystinuria (COMPOSE)France FranceNot Yet Recruiting

Data & Insights

science
Molecule Portfolio
Compounds under investigation
1
Exclusive Molecules
out of 3 total (33% not shared with other sponsors)

This sponsor works with 3 molecules, of which 1 is not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
26%
Return partnership rate
27 of 103 sites collaborated multiple times

This sponsor has worked with 103 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Pathological Conditions, Signs and Symptoms3 trials
    91 other sponsors
  • 2.
    Nutritional and Metabolic Diseases2 trials
    211 other sponsors

Partnered Research Centres

103 centres
location_city
assignment52
Alessandro Manzoni Hospital
Address
Via Dell' Eremo 9, 23900 Lecco
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location_city
assignment283
Algemeen Ziekenhuis Delta
Address
Deltalaan 1, 8800 Roeselare
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location_city
assignment163
Algemeen Ziekenhuis Groeninge
Address
President Kennedylaan 4, 8500 Kortrijk
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location_city
assignment155
Amsterdam UMC
Address
Meibergdreef 9, 1105 AZ Amsterdam
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location_city
assignment966
Assistance Publique Hopitaux De Marseille
Address
264 Rue Saint Pierre, 13005 Marseille
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location_city
assignment478
Assistance Publique Hopitaux De Paris
Address
Num Voie 47 A 83, 47 Boulevard De L Hopital, 75013 Paris
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