Theravance Biopharma Ireland Limited
- Address
- 10 Earlsfort Terrace
Sponsor Overview
Specializations
Autonomic Nervous System Disorders
Theravance Biopharma Ireland Limited is engaged in clinical research focused on neurogenic orthostatic hypotension, a condition linked to impaired autonomic regulation of blood pressure and symptoms related to standing.
- Symptomatic nOH
- Orthostatic intolerance
- Blood pressure dysregulation
The sponsor’s research activity in this area is closely associated with disorders affecting autonomic function, including patients with multiple system atrophy.
Multiple System Atrophy
The clinical programme includes studies in multiple system atrophy, with attention to the vascular and neurological complications that contribute to symptomatic burden in affected participants.
- Neurodegenerative disease
- Autonomic failure
- Postural symptoms
This area reflects interest in managing manifestations of MSA that interfere with daily function and cardiovascular stability.
Cardiovascular Symptom Control
Research activity also addresses cardiovascular symptoms arising from impaired autonomic control, with a focus on standing-related dizziness, lightheadedness, and related hemodynamic effects.
- Orthostatic dizziness
- Syncope-related symptoms
- Hemodynamic instability
These interests align with therapeutic strategies aimed at improving symptom persistence and functional comfort in people living with nOH.
Neurology-Related Therapeutics
The sponsor’s clinical research landscape sits within neurology, particularly conditions where autonomic dysfunction intersects with progressive neurological disease.
- Autonomic symptoms
- Neurological disability
- Patient-reported symptom burden
Its funded research reflects a therapeutic interest in disorders where neurological and cardiovascular manifestations occur together.
Sponsored Trials
| Trial Name | Country | Status |
|---|---|---|
| Efficacy and Durability of Ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Multiple System Atrophy: A Phase 3 Study |  Austria Belgium Denmark Estonia France Germany Hungary Italy Poland Portugal Spain | Not Recruiting |
Data & Insights
This sponsor works with 2 molecules, of which 2 are not being studied by other sponsors.
This sponsor has worked with 34 sites across their trial portfolio.
Therapeutic Focus
- 1.Cardiovascular Diseases1 trial359 other sponsors
Partnered Research Centres
34 centres- Address
- Biocruces Bizkaia Health Research Center Institute, Neurology Sevice- Cruces University Hospital, Edificio Biocruces 1-4a Planta Grupo de Enfermedades Neurodegenerativas, Plaza Cruces s/n, 48903 Barakaldo
- Address
- Azienda Opspedaliera Universitaria Policlinico, Tor Vergata, Via Carlo Mirabello 18, 00195 Rome
- Address
- Via Santa Sofia 78, 95123 Catania
- Address
- PURPAN Hall D – 2ième étage Place du Dr Baylac, 31059 cedex 9 Toulouse
- Address
- Centre Hospitalier Universitaire de Bordeaux, Service de Neurologie-Maladies Neuro-degeneraties, IMNc, 2eme etage, Place Amelie Raba Leon, 33076 Bordeaux
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