Spruce Biosciences Inc.
- Address
- 611 Gateway Boulevard Suite 740
Sponsor Overview
Specializations
Endocrine Disorders
Spruce Biosciences Inc. focuses on classic congenital adrenal hyperplasia, with clinical research centered on the hormonal and metabolic consequences of this inherited endocrine disorder.
- Congenital adrenal hyperplasia
- Adrenal hormone imbalance
- Glucocorticoid-related management
Its research activity is directed toward patients with persistent adrenal steroid dysregulation and elevated blood hormone levels associated with this condition.
Hormonal Biomarker Modulation
The sponsor’s studies examine therapeutic interest in reducing excess androstenedione and adjusting glucocorticoid burden in adults living with classic CAH.
- Androstenedione reduction
- Glucocorticoid sparing
- Blood hormone control
This places emphasis on managing the biochemical features that define the disorder rather than broader multisystem disease areas.
Rare Disease Therapeutics
Spruce Biosciences is active in the rare disease space, with research concentrated on a narrowly defined patient population affected by a lifelong adrenal condition.
- Rare endocrine disease
- Adult congenital adrenal hyperplasia
- Inherited adrenal conditions
The funded trials reflect interest in therapeutic options for a specialized population with limited treatment-focused research.
Adrenal Steroid Regulation
Clinical research activity includes attention to adrenal steroid regulation and the control of hormone excess linked to classic CAH.
- Adrenal steroid excess
- Hormone suppression
- Endocrine homeostasis
These studies align with therapeutic interest in improving biochemical control in patients with chronic adrenal hormone abnormalities.
Sponsored Trials
| Trial Name | Country | Status |
|---|---|---|
| Efficacy and Safety Evaluation of Tildacerfont and Hydrocortisone in Adults with Classic Congenital Adrenal Hyperplasia: A Randomized, Double-Blind, Placebo-Controlled Study |  Denmark Estonia Germany Ireland Italy Latvia Lithuania Poland Romania Spain Sweden The Netherlands | Not Recruiting |
| Evaluation of Tildacerfont in Reducing Supraphysiologic Glucocorticoid Use in Adults with Classic Congenital Adrenal Hyperplasia: A Randomized, Double-Blind, Placebo-Controlled Trial | Denmark Estonia Germany Ireland Italy Latvia Lithuania Poland Romania Spain Sweden The Netherlands | Not Recruiting |
Data & Insights
This sponsor works with 3 molecules, of which 1 is not being studied by other sponsors.
This sponsor has worked with 29 sites across their trial portfolio.
Therapeutic Focus
- 1.Genetic Phenomena2 trials26 other sponsors
Partnered Research Centres
29 centres- Address
- Palle Juul-Jensens Boulevard 99, 8200 Aarhus
- Address
- Via Cherasco 15, 10126 Turin
- Address
- Via Sergio Pansini 5, 80131 Naples
- Address
- Via Di Grottarossa 1035-1039, 00189 Rome
- Address
- Beaumont Road, Beaumont, D09 V2N0 Dublin
- Address
- Ravi Tn 18, Kesklinna Linnaosa, 10138 Tallin
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