Radboud universitair medisch centrum Stichting

The sponsor is actively involved in studies of cardiovascular disease, with emphasis on coronary vasospasm, coronary microvascular dysfunction, angina, heart failure, hypertension, peripheral arterial disease, acute myocardial infarction, and aortic valve stenosis.

• Coronary vasomotor disorders
• Aortic valve disease and aortic valve calcification
• Stroke, intracerebral haemorrhage, and subarachnoid hemorrhage
• Antithrombotic therapy and vascular protection

Research in this area also includes blood pressure management, vascular imaging, and treatment approaches for ischemic and hemorrhagic cerebrovascular disease.

Clinical studies cover fungal infection, candidemia, tuberculosis, nontuberculous mycobacterial disease, pertussis, sepsis, and HIV infection, alongside immune-mediated conditions such as systemic sclerosis, Sjögren's syndrome, primary membranous nephropathy, and inflammatory bowel disease.

• Antifungal and antimicrobial treatment research
• Host immune response and inflammation
• Vaccine immunogenicity and infection prevention
• Autoimmune and immune-mediated renal disease

The sponsor also investigates experimental endotoxemia, immunomodulation, and inflammatory mechanisms linked to acute and chronic disease.

Its research portfolio includes Parkinson's disease, chronic cluster headache, dystonic tremor syndrome, delirium, major depressive disorder, posttraumatic stress disorder, anxiety, fatigue, and GHB use disorder.

• Movement disorders and tremor syndromes
• Mood disorders and trauma-related conditions
• Substance use disorder and detoxification
• Neurological injury and cognitive complications

Additional work addresses stroke recovery, intracerebral bleeding, and symptom control in chronic pain and neurological disease.

The sponsor funds studies in type 1 diabetes, gestational diabetes, diabetic foot ulcer, chronic pancreatitis, predicted severe acute pancreatitis, primary aldosteronism, hypomagnesemia, and primary membranous nephropathy.

• Diabetes-related complications
• Pancreatic inflammation and gastrointestinal disease
• Kidney disease and electrolyte disorders
• Hormonal and metabolic regulation

Research also includes nutrition-related interventions, organ failure prevention, and disease management in complex multisystem conditions.