Karolinska University Hospital

Address
Eugeniavagen 3

Sponsor Overview

assignment
59
sponsored trials
science
109
molecules
location_city
174
research centres
public
18
countries
person_search
411
investigators

Specializations

Oncology and Haematologic Malignancies

Karolinska University Hospital supports clinical research across a broad range of cancer types, with particular activity in breast cancer, lung cancer, melanoma, gastrointestinal cancers, and gynaecological malignancies. Its portfolio also includes leukaemia, lymphoma, myelodysplastic syndrome, and neuroblastoma.

  • HER2-positive and HER2-low breast cancer
  • Acute myeloid leukaemia and acute lymphoblastic leukaemia
  • Follicular lymphoma and other non-Hodgkin lymphoma subtypes
  • Esophageal, gastric, pancreatic, and colorectal cancer
  • Advanced solid tumours and metastatic melanoma

Research activity also extends to molecular imaging and biomarker-driven assessment in oncology, including work focused on tumour expression profiling and treatment selection.

Cardiovascular and Renal Medicine

The hospital funds studies in cardiovascular disease and kidney disease, with emphasis on rhythm disorders, thromboembolic prevention, and high-risk clinical settings. Areas of interest include atrial fibrillation, cardiac arrest, and treatment-resistant hypertension.

  • Atrial fibrillation and post-procedural rhythm control
  • Cardiac arrest and resuscitation care
  • Chronic kidney disease stage 5
  • Stroke prevention in patients with atrial fibrillation
  • Resistant hypertension

Its research also covers cardiovascular risk in complex comorbidity settings, including patients with advanced renal impairment and those undergoing invasive cardiac treatment.

Autoimmune, Inflammatory, and Transplant-Related Disorders

Clinical studies at the hospital address rheumatoid arthritis, immune-related arthritis, primary sclerosing cholangitis, and hepatitis D, alongside immune-mediated complications in oncology and transplantation. The portfolio includes work in liver transplantation and strategies related to immune tolerance.

  • Rheumatoid arthritis and disease control
  • Immune checkpoint inhibitor-associated arthritis
  • Primary sclerosing cholangitis
  • Chronic hepatitis D
  • Liver transplantation and immune modulation

Research also includes allergen immunotherapy and other immune-directed interventions in chronic inflammatory and hypersensitivity conditions.

Neurology, Endocrinology, and Metabolic Disease

The sponsor funds trials in Parkinson's disease, brain tumour-related survivorship, type 1 diabetes, type 2 diabetes, and thyroid disease. Additional interest is seen in endocrine and metabolic disorders affecting reproductive and systemic health.

  • Parkinson's disease
  • Diabetes mellitus and metabolic dysfunction
  • Hyperthyroidism and toxic nodular goiter
  • Brain tumour survivorship and cognitive effects
  • Ovarian insufficiency and reproductive endocrinology

Its clinical research also includes attention to endocrine consequences of cancer treatment and hormone-related conditions, including climacteric symptoms and fertility-related outcomes.

Surgical Recovery, Reproductive Health, and Rare Conditions

Karolinska University Hospital also supports studies in post-operative recovery, female reproductive health, and selected rare or specialised conditions. These include recovery after major gastrointestinal and orthopaedic surgery, as well as disorders affecting sexual development and gender identity.

  • Post-operative recovery after hip fracture surgery
  • Recovery after gastrectomy or esophagectomy
  • Autoimmune premature ovarian insufficiency
  • Gender dysphoria and transsexual health
  • Rare dermatologic and genetic disorders

Research in this area also includes fertility preservation, ovarian reserve, and symptom management in complex chronic disease settings.

Sponsored Trials

Trial Name Country Status
A Randomized Trial of Trastuzumab Deruxtecan and Biology-Driven Selection of Neoadjuvant Treatment for HER2-positive Breast Cancer: ARIADNEBelgium BelgiumNorway NorwaySweden SwedenThe Netherlands The NetherlandsRecruiting
A Study of KRA-533 in Advanced KRASG12C-Mutated Non-Small Cell Lung Cancer Patients with Prior Therapy Progression or Immuno/Chemotherapy ContraindicationsSweden SwedenNot Yet Recruiting
ALLTogether1 - A Treatment Study Protocol of the ALLTogether Consortium for Children and Young Adults (0-45 Years of Age) with Newly Diagnosed Acute Lymphoblastic Leukaemia (ALL)Belgium BelgiumDenmark DenmarkEstonia EstoniaFinland FinlandFrance FranceGermany GermanyIceland IcelandIreland IrelandLithuania LithuaniaNorway NorwayPortugal PortugalSpain SpainSweden SwedenThe Netherlands The NetherlandsRecruiting
CITAR - Comparison of the efficacy and safety of early use of IL-6R blockade with tocilizumab in combination with short-term glucocorticoids versus glucocorticoids alone for the treatment of arthritis induced by cancer immunotherapy by check point inhibitors: a randomized, open, multicentre, proof of concept, superiority, controlled clinical trialFrance FranceSweden SwedenRecruiting
Comparison of Conventional Salvage Radiotherapy and Individualized PSMA-PET/CT Targeted Treatment in Biochemical Recurrence Post-Prostatectomy Using 18F-PSMA-1007 and GozetotideSweden SwedenRecruiting
Efficacy of Fluoxetine and Internet-Based Cognitive Behavioral Therapy in Reducing Problematic Sexual Behaviors in Men with Pedophilic DisorderSweden SwedenRecruiting
Efficacy of Lithium Sulphate in Preventing Cognitive Processing Speed Impairment Post-CNS Radiotherapy in Pediatric Brain Tumor PatientsDenmark DenmarkSweden SwedenRecruiting
Efficacy of Rituximab in Restoring Ovarian Function in Autoimmune Premature Ovarian Insufficiency: A Double-Blind, Placebo-Controlled, Randomized TrialSweden SwedenNot Yet Recruiting
Evaluation of 68Ga-FAPI-46 PET Imaging for Non-Invasive Diagnosis of Desmoplastic Tumors in Pancreatic, Biliary, Gastric, and Ovarian CancersFinland FinlandSweden SwedenRecruiting
Evaluation of [68Ga]Ga-ABY-025 PET Imaging for HER2 Expression and Predictive Value of Trastuzumab Deruxtecan in Metastatic Breast CancerSweden SwedenNot Yet Recruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
4
Exclusive Molecules
out of 109 total (4% not shared with other sponsors)

This sponsor works with 109 molecules, of which 4 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
38%
Return partnership rate
66 of 174 sites collaborated multiple times

This sponsor has worked with 174 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Neoplasms28 trials
    853 other sponsors
  • 2.
    Hemic and Lymphatic Diseases7 trials
    249 other sponsors
  • 3.
    Cardiovascular Diseases5 trials
    359 other sponsors
  • 4.
    Diagnosis3 trials
    83 other sponsors
  • 5.
    Immune System Diseases3 trials
    322 other sponsors
  • 6.
    Musculoskeletal Diseases3 trials
    238 other sponsors
  • 7.
    Nervous System Diseases3 trials
    449 other sponsors
  • 8.
    Nutritional and Metabolic Diseases3 trials
    211 other sponsors
  • 9.
    Digestive System Diseases2 trials
    280 other sponsors
  • 10.
    Female Urogenital Diseases and Pregnancy Complications2 trials
    142 other sponsors
  • 11.
    Hormonal diseases2 trials
    89 other sponsors
  • 12.
    Mental Disorders2 trials
    150 other sponsors
  • 13.
    Immune System Phenomena1 trial
    15 other sponsors
  • 14.
    Investigative Techniques1 trial
    35 other sponsors
  • 15.
    Metabolism1 trial
    38 other sponsors
  • 16.
    Skin and Connective Tissue Diseases1 trial
    247 other sponsors
  • 17.
    Virus Diseases1 trial
    182 other sponsors

Partnered Research Centres

174 centres
location_city
assignment335
Aalborg University Hospital
Address
Moelleparkvej 4, 9000 Aalborg
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location_city
assignment352
Aarhus University Hospital
Address
Palle Juul-Jensens Boulevard 99, 8200 Aarhus
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location_city
assignment185
Akershus University Hospital
Address
Sykehusveien 25, 1474 Lorenskog
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location_city
assignment680
Amsterdam UMC
Address
De Boelelaan 1117, 1081 HV Amsterdam
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location_city
assignment966
Assistance Publique Hopitaux De Marseille
Address
264 Rue Saint Pierre, 13005 Marseille
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location_city
assignment478
Assistance Publique Hopitaux De Paris
Address
Num Voie 47 A 83, 47 Boulevard De L Hopital, 75013 Paris
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