Clinical Research

Hospices Civils De Lyon

Address
3 Quai Des Celestins, Bp 2251

Sponsor Overview

assignment
41
sponsored trials
science
77
molecules
location_city
116
research centres
public
1
country
person_search
350
investigators

Specializations

Oncology and rare cancers

Clinical research covers advanced and metastatic solid tumours, with particular attention to mesothelioma, gastric adenocarcinoma, ovarian cancer, neuroendocrine carcinoma, thymic malignancies, anaplastic thyroid carcinoma, and gestational trophoblastic neoplasia. The portfolio also includes studies in metastatic prostate cancer and other treatment-resistant cancers.

  • Malignant pleural and peritoneal mesothelioma
  • Advanced gastric cancer
  • Rare thoracic and endocrine tumours
  • Gastro-enteropancreatic neuroendocrine neoplasms

Research interest extends to immunotherapy, targeted cancer treatment, and surgical or locoregional management in advanced disease.

Neurology, neuroimaging, and movement disorders

Trials address Parkinson disease, Tourette disorder, epilepsy, cluster headache, stroke, intracerebral haemorrhage, transient ischemic attack, and broader nervous system diseases. Several studies focus on brain receptor pathways, functional connectivity, and inflammatory imaging markers.

  • Parkinson disease
  • Epilepsy and seizure disorders
  • Tourette disorder
  • Stroke and cerebrovascular disease

There is also interest in PET-MRI, serotonergic pathways, and adrenergic receptor biology.

Pulmonary, critical care, and infectious disease

The sponsor funds studies in asthma, idiopathic pulmonary fibrosis, ventilator-acquired pneumonia, and septic shock. Research also includes inflammatory and immune-related respiratory conditions such as extra-pulmonary sarcoidosis.

  • Asthma
  • Idiopathic pulmonary fibrosis
  • Ventilator-acquired pneumonia
  • Septic shock

Additional work explores immune modulation in acute infection and respiratory failure.

Autoimmune, transplant, and haematology

Clinical activity includes systemic lupus erythematosus, ANCA-associated vasculitis, granulomatosis with polyangiitis, microscopic polyangiitis, renal transplantation, and allogeneic haematopoietic stem cell transplantation. These studies reflect interest in immune-mediated disease, graft outcomes, and transplant-related immunosuppression.

  • Systemic lupus erythematosus
  • ANCA-associated vasculitis
  • Kidney transplantation
  • Haematopoietic stem cell transplantation

Research also touches on graft rejection and immune recovery after transplantation.

Dermatology, ophthalmology, and paediatric care

Further trials involve Stevens-Johnson syndrome, toxic epidermal necrolysis, bilateral limbal stem cell deficiency, diabetic macular oedema, and cerebral palsy with pathological drooling. The portfolio also includes obesity in children and adolescents, postoperative pain, and drug dependence.

  • Severe bullous skin reactions
  • Limbal stem cell deficiency
  • Diabetic macular oedema
  • Paediatric neurological and functional disorders

These studies span skin regeneration, vision-threatening disease, and supportive care in paediatrics.

Sponsored Trials

Trial Name Country Status
[18F]CPFPX PET Assessment of Brainstem Adenosine A1 Receptor Distribution in Drug-Resistant Epilepsy Under Hypercapnic ChallengeFrance FranceNot Yet Recruiting
A RANDOMIZED DOUBLE BLIND, PLACEBO-CONTROLLED NATIONAL MULTICENTER PHASE 3 TRIAL TO EVALUATE THE EFFICACY OF AZATHIOPRINE FOR THE PREVENTION OF RELAPSE IN PATIENTS WITH MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY ASSOCIATED DISEASE (MOG-AD) AFTER A FIRST ATTACK : MOGWAIFrance FranceRecruiting
Assessment of [18F]Befiradol in PET-MRI for Pathophysiological Analysis of Episodic Cluster Headache in Active vs. Inactive Disease PhasesFrance FranceRecruiting
Assessment of Ficolin-2 Levels and Carotid and Brain Inflammation in Symptomatic Carotid Stenosis Using [18F]DPA-714 PET/MRI in Stroke or Transient Ischemic AttackFrance FranceNot Recruiting
Assessment of Filgrastim Efficacy in Patients with Severe Bullous Drug Eruptions: Lyell Syndrome and Stevens-Johnson SyndromeFrance FranceRecruiting
BACLOFEN FOR IMPROVING BENZODIAZEPINE TITRATION IN BENZODIAZEPINE DEPENDENCE. BABETFrance FranceRecruiting
Efficacy Comparison of Monthly Bolus Versus Daily Colecalciferol Supplementation in Correcting Vitamin D Deficiency in Obese Pediatric PatientsFrance FranceRecruiting
Efficacy of Dexmedetomidine as Adjunctive Therapy for Refractory Septic Shock in Mechanically Ventilated Patients: A Randomized Controlled TrialFrance FranceNot Yet Recruiting
Efficacy of Nintedanib in Reducing Epistaxis Duration in Hereditary Hemorrhagic Telangiectasia: A Phase II Randomized Controlled TrialFrance FranceNot Recruiting
Efficacy of prophylactic levetiracetam on functional outcomes in patients with acute intracerebral haemorrhage: a phase 3, randomised, double-blind, placebo-controlled trialFrance FranceNot Yet Recruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
7
Exclusive Molecules
out of 77 total (9% not shared with other sponsors)

This sponsor works with 77 molecules, of which 7 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
45%
Return partnership rate
52 of 116 sites collaborated multiple times

This sponsor has worked with 116 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Nervous System Diseases9 trials
    449 other sponsors
  • 2.
    Neoplasms6 trials
    853 other sponsors
  • 3.
    Female Urogenital Diseases and Pregnancy Complications3 trials
    142 other sponsors
  • 4.
    Respiratory Tract Diseases3 trials
    277 other sponsors
  • 5.
    Digestive System Diseases2 trials
    280 other sponsors
  • 6.
    Eye Diseases2 trials
    138 other sponsors
  • 7.
    Immune System Diseases2 trials
    322 other sponsors
  • 8.
    Male Urogenital Diseases2 trials
    111 other sponsors
  • 9.
    Not possible to specify2 trials
    220 other sponsors
  • 10.
    Nutritional and Metabolic Diseases2 trials
    211 other sponsors
  • 11.
    Skin and Connective Tissue Diseases2 trials
    247 other sponsors
  • 12.
    Surgical Procedures, Operative2 trials
    58 other sponsors
  • 13.
    Behavioral Disciplines and Activities1 trial
    20 other sponsors
  • 14.
    Cardiovascular Diseases1 trial
    359 other sponsors
  • 15.
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities1 trial
    165 other sponsors
  • 16.
    Hemic and Lymphatic Diseases1 trial
    249 other sponsors
  • 17.
    Immune system processes1 trial
    65 other sponsors
  • 18.
    Investigative Techniques1 trial
    35 other sponsors
  • 19.
    Musculoskeletal and Neural Physiological Phenomena1 trial
    28 other sponsors

Partnered Research Centres

116 centres
location_city
assignment57
Aix Marseille University
Address
264 Boulevard de Saint Pierre, 13005 Marseille
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location_city
assignment966
Assistance Publique Hopitaux De Marseille
Address
264 Rue Saint Pierre, 13005 Marseille
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location_city
assignment77
Assistance Publique Hopitaux De Paris
Address
27 Rue du Faubourg Saint-Jacques, 75014 Paris
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location_city
assignment72
Assistance Publique Hopitaux De Paris
Address
46 Rue Henri Huchard, 75877 Paris
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location_city
assignment478
Assistance Publique Hopitaux De Paris
Address
Num Voie 47 A 83, 47 Boulevard De L Hopital, 75013 Paris
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location_city
assignment88
Assistance Publique Hopitaux De Paris
Address
26 Avenue Du Docteur Arnold Netter, 75012 Paris
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