Clinical Research

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Address
Largo Francesco Vito 1

Sponsor Overview

assignment
24
sponsored trials
science
57
molecules
location_city
90
research centres
public
5
countries
person_search
146
investigators

Specializations

Gynecologic Oncology

Clinical research in ovarian cancer, fallopian tube cancer, and primary peritoneal cancer includes advanced, recurrent, platinum-resistant, and HRD-guided treatment strategies, as well as studies in patients with disease involving the pelvis and peritoneum.

  • Advanced and recurrent ovarian malignancies
  • Platinum-resistant disease
  • Pelvic exenteration in gynecologic cancer
  • Pre-neoplastic vulvar and cervical lesions
  • Vulvar Paget's disease

Interest also extends to electrochemotherapy, pembrolizumab-based approaches, and biomarker-informed management of HPV-related and invasive gynecologic lesions.

Genitourinary and Renal Cancer

The sponsor supports studies in metastatic castration-resistant prostate cancer, metastatic renal cell carcinoma, urothelial cancer, and muscle-invasive bladder cancer, with attention to molecular features that may guide treatment selection.

  • Prostate cancer with BRCA-negative or unknown status
  • Renal cell carcinoma
  • Urothelial carcinoma
  • Bladder cancer
  • DDR gene alterations

Research activity also includes immunotherapy combinations, platinum sensitivity, and surgical oncology questions in advanced urinary tract malignancies.

Thoracic, Colorectal, and Melanoma Oncology

Ongoing work covers EGFR-mutant non-small cell lung cancer, metastatic colorectal cancer with BRAF V600E mutation, and metastatic uveal melanoma, reflecting a strong focus on molecularly defined solid tumors.

  • EGFR-mutant NSCLC
  • BRAF V600E-mutated metastatic colorectal cancer
  • Uveal melanoma
  • HER2-positive breast cancer
  • Targeted therapy and immunotherapy

These studies include biomarker-driven treatment in TP53-defined lung cancer and resistance monitoring in HER2-directed therapy.

Autoimmune, Neuromuscular, and Neuro-Oncology Disorders

Non-oncologic research includes generalized myasthenia gravis, refractory systemic autoimmune diseases, connective tissue disease-associated interstitial lung disease, and optic pathway glioma in children and young adults.

  • Myasthenia gravis
  • Systemic autoimmune disease
  • Connective tissue disease-associated interstitial lung disease
  • Optic pathway glioma
  • Neuroimmunology

Additional interest is shown in CAR T-cell therapy, rituximab, and visual function preservation in pediatric neuro-oncology.

Cardiometabolic and Psychiatric Research

The portfolio also includes myocardial infarction with non-obstructive coronary arteries, treatment-resistant depression, obesity, and type 2 diabetes, indicating activity across cardiovascular, metabolic, and mental health domains.

  • MINOCA
  • Treatment-resistant depression
  • Obesity
  • Type 2 diabetes
  • Precision medicine

Research in this area includes biomarker-based phenotyping, brain imaging of neurotransporter function, and treatment response assessment in metabolic disease.

Sponsored Trials

Trial Name Country Status
Assessment of P-glycoprotein Activity in Treatment-Resistant Depression Using [18F]MC225 PET/CT ImagingItaly ItalyRecruiting
Efficacy of Osimertinib in Treatment-Naïve Patients with EGFR Mutant NSCLC Stratified by TP53 Mutational StatusItaly ItalyNot Recruiting
Evaluation of [18F]FAPI-74 PET/CT Imaging for Early Detection of Progressive Lung Fibrosis in Connective Tissue Disease-Associated Interstitial Lung DiseaseItaly ItalyNot Recruiting
Evaluation of Anti-CD19 CAR T-Cell Therapy in Refractory Systemic Autoimmune Diseases: A Study of Autologous T-Cells with Drug CombinationItaly ItalyRecruiting
Evaluation of Cisplatin, Nab-Paclitaxel, and Nivolumab with Radiotherapy Post-Maximal Tumor Resection in Non-Metastatic Muscle-Invasive Bladder CancerItaly ItalyRecruiting
Evaluation of Dapagliflozin and Oral Semaglutide in Phenotyping and Personalized Treatment of Type 2 Diabetes Based on Insulin Resistance and Secretion DeficitItaly ItalyRecruiting
Evaluation of DDR Gene Alterations in Predicting Response to Platinum-Based Chemotherapy in Metastatic or Locally Advanced Urothelial CancerItaly ItalyRecruiting
Evaluation of Encorafenib and Cetuximab with FOLFIRI in BRAF V600E Mutated Metastatic Colorectal Cancer Post-Progression on Encorafenib and CetuximabItaly ItalyNot Recruiting
Evaluation of Esomeprazole on Structural Integrity Post-Endoscopic Sleeve Gastroplasty in Obesity: A Randomized Controlled Pilot StudyItaly ItalyRecruiting
Evaluation of Hepatic Radiotherapy Combined with Tebentafusp in HLA A*02:01 Positive Metastatic Uveal Melanoma PatientsItaly ItalyRecruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
4
Exclusive Molecules
out of 57 total (7% not shared with other sponsors)

This sponsor works with 57 molecules, of which 4 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
44%
Return partnership rate
40 of 90 sites collaborated multiple times

This sponsor has worked with 90 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Neoplasms16 trials
    853 other sponsors
  • 2.
    Digestive System Diseases2 trials
    280 other sponsors
  • 3.
    Nutritional and Metabolic Diseases2 trials
    211 other sponsors
  • 4.
    Cardiovascular Diseases1 trial
    359 other sponsors
  • 5.
    Eye Diseases1 trial
    138 other sponsors
  • 6.
    Immune System Diseases1 trial
    322 other sponsors
  • 7.
    Mental Disorders1 trial
    150 other sponsors
  • 8.
    Metabolism1 trial
    38 other sponsors
  • 9.
    Nervous System Diseases1 trial
    449 other sponsors
  • 10.
    Respiratory Tract Diseases1 trial
    277 other sponsors
  • 11.
    Skin and Connective Tissue Diseases1 trial
    247 other sponsors

Partnered Research Centres

90 centres
location_city
assignment5
AOU Ospedali Riuniti Umberto I°-Lancisi-Salesi di Ancona
Address
via Conca 71, 60126 Torrette (AN), Ancona
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location_city
assignment47
ARNAS Civico Di Cristina Benfratelli
Address
Piazza Nicola Leotta 4, 90127 Palermo
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location_city
assignment49
ARNAS Garibaldi Di Catania
Address
Piazza Santa Maria Di Gesu, 95123 Catania
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location_city
assignment6
ASL PESCARA-Presidio Ospedaliero Pescara
Address
Via Fonte Romana 8, 65124 Pescara
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location_city
assignment413
ASST Grande Ospedale Metropolitano Niguarda
Address
Piazza Dell'ospedale Maggiore 3, 20162 Milan
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location_city
assignment147
Azienda Ospedaliera Ordine Mauriziano Di Torino
Address
Via Ferdinando Magellano 1, 10128 Turin
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