Fondazione Italiana Linfomi Ets

Address
Piazza Filippo Turati 5

Sponsor Overview

assignment
15
sponsored trials
science
32
molecules
location_city
93
research centres
public
1
country
person_search
155
investigators

Specializations

Follicular lymphoma and related indolent B-cell lymphomas

Clinical research in follicular lymphoma includes relapsed and refractory disease, early-stage presentations, and high-tumor-burden cases, with a strong focus on immunotherapy, anti-CD20 therapy, and maintenance treatment strategies.

  • Follicular lymphoma
  • Early stage follicular lymphoma
  • Relapsed or refractory follicular lymphoma
  • High tumor burden disease

Research activity also extends to treatment adaptation in older patients and approaches aimed at limiting exposure to conventional chemotherapy while preserving disease control.

Diffuse large B-cell lymphoma and aggressive B-cell disease

The sponsor supports studies in diffuse large B-cell lymphoma, including ABC-DLBCL, elderly patients with newly diagnosed disease, and frail populations unsuitable for standard regimens, with interest in chemo-free approaches and immunochemotherapy.

  • Diffuse large B-cell lymphoma
  • ABC-DLBCL
  • Elderly patients with DLBCL
  • Non-Hodgkin lymphoma

Its trial portfolio also includes interventions for aggressive B-cell lymphoma subtypes requiring treatment refinement in older or medically unfit patients.

Hodgkin lymphoma and transplant-adjacent salvage care

Research in Hodgkin lymphoma addresses patients who are unsuitable for standard chemotherapy as well as relapsed or refractory disease requiring salvage treatment and consideration of autologous stem-cell transplantation.

  • Hodgkin lymphoma
  • Hodgkin’s lymphoma
  • Relapsed or refractory disease
  • Transplant-eligible salvage settings

These studies reflect interest in checkpoint inhibition and other non-standard options for patients with limited tolerance to conventional therapy.

Mantle cell lymphoma and advanced targeted therapy

Clinical activity in mantle cell lymphoma spans untreated elderly patients, high-risk disease, relapsed or refractory settings, and post-CAR-T relapse, with emphasis on BTK inhibition, BCL-2 targeting, and bispecific antibodies.

  • Mantle cell lymphoma
  • Relapsed or refractory mantle cell lymphoma
  • BTK inhibitor-treated disease
  • Post CAR-T relapse

The portfolio also includes consolidation and frontline strategies for frail or high-risk patients with this lymphoma subtype.

T-cell lymphomas and rare plasma cell lymphoma

The sponsor funds research in T-cell lymphomas, including anaplastic large T-cell lymphoma, angioimmunoblastic T-cell lymphoma, and peripheral T-cell lymphoma, alongside studies in plasmablastic lymphoma, a rare and aggressive lymphoid malignancy.

  • Anaplastic large T-cell lymphoma
  • Angioimmunoblastic T-cell lymphoma
  • Peripheral T-cell lymphoma
  • Plasmablastic lymphoma

These trials are centered on difficult-to-treat disease biology and the use of targeted agents and immunotherapy in uncommon lymphoma subtypes.

Sponsored Trials

Trial Name Country Status
An open-label, randomized phase III trial comparing local radiotherapy alone or combined with Obinutuzumab in early stage Follicular Lymphoma: the GAZEBO Trial from the Fondazione Italiana LinfomiItaly ItalyRecruiting
Efficacy and Safety of Ibrutinib with Rituximab-CHOP and Maintenance Ibrutinib in Untreated Intermediate-High/High-Risk ABC-DLBCL PatientsItaly ItalyNot Recruiting
Evaluation of Daratumumab, Bortezomib, and Dexamethasone in Relapsed/Refractory Plasmablastic Lymphoma Patients Ineligible for TransplantationItaly ItalyRecruiting
Evaluation of Venetoclax Addition to Rituximab, Bendamustine, and Cytarabine Regimen in High-Risk Elderly Patients with Mantle Cell LymphomaItaly ItalyNot Recruiting
Phase I-II Study of Romidepsin Combined with CHOEP for Initial Treatment in Young Patients with Nodal Peripheral T-Cell Lymphomas Prior to Hematopoietic Stem Cell TransplantationItaly ItalyNot Recruiting
Phase I/IIb Study of Atezolizumab with BEGEV Regimen in Relapsed/Refractory Hodgkin's Lymphoma for Autologous Stem-Cell Transplantation CandidatesItaly ItalyRecruiting
Phase II Evaluation of Loncastuximab Tesirine Consolidation Post-Immunochemotherapy in BTKi-Treated or Intolerant Relapsed/Refractory Mantle Cell LymphomaItaly ItalyNot Recruiting
Phase II Evaluation of Mosunetuzumab and Zanubrutinib in Relapsed/Refractory Follicular LymphomaItaly ItalyNot Recruiting
Phase II Evaluation of Rituximab and Golcadomide Combination Therapy in Frail Elderly Patients with Diffuse Large B-Cell Non-Hodgkin LymphomaItaly ItalyRecruiting
Phase II Evaluation of Tislelizumab Efficacy and Safety in De Novo Hodgkin Lymphoma Patients Ineligible for Standard ChemotherapyItaly ItalyRecruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
1
Exclusive Molecules
out of 32 total (3% not shared with other sponsors)

This sponsor works with 32 molecules, of which 1 is not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
72%
Return partnership rate
67 of 93 sites collaborated multiple times

This sponsor has worked with 93 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Hemic and Lymphatic Diseases15 trials
    249 other sponsors

Partnered Research Centres

93 centres
location_city
assignment66
AORN San Giuseppe Moscati Avellino
Address
Contrada Amoretta, 83100 Avellino
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location_city
assignment57
ARNAS G. Brotzu
Address
Piazzale Alessandro Ricchi 1, 09121 Cagliari
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location_city
assignment3
ASL di Salerno - PO Andrea tortora
Address
Via Alcide De Gasperi, 184016 Pagani
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location_city
assignment6
ASL PESCARA-Presidio Ospedaliero Pescara
Address
Via Fonte Romana 8, 65124 Pescara
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location_city
assignment2
ASL Roma1
Address
Borgo Santo Spirito 3, 00193 Rome
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location_city
assignment413
ASST Grande Ospedale Metropolitano Niguarda
Address
Piazza Dell'ospedale Maggiore 3, 20162 Milan
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