Charite Universitaetsmedizin Berlin KöR

Address: Chariteplatz 1, Mitte

Sponsor Overview

assignment

Specializations

Autoimmune and Inflammatory Diseases

Autoimmune disease research includes ANCA-associated vasculitis, rheumatoid arthritis, axial spondyloarthritis, localized scleroderma, plaque psoriasis, and chronic hand eczema, with additional work in immune-mediated tissue inflammation.

ANCA-associated vasculitis
Rheumatoid arthritis
Psoriasis and eczema
Scleroderma and spondyloarthritis

These studies also extend to immune-cell targeted approaches and inflammatory skin and joint conditions.

Oncology and Hematologic Malignancies

Oncology activity spans acute lymphoblastic leukemia, metastatic colorectal cancer, head and neck cancer, and lung adenocarcinoma, alongside treatment strategies for advanced solid tumors.

Relapsed acute lymphoblastic leukemia
Metastatic colorectal cancer
Head and neck cancer
Lung adenocarcinoma

Research in this area includes immunotherapy, combination systemic therapy, and approaches for recurrent or metastatic disease.

Transplantation and Immune Tolerance

Kidney transplantation and liver transplantation studies focus on graft tolerance, immune modulation, and reduction of long-term immunosuppression requirements.

Kidney transplant recipients
Liver transplant recipients
Regulatory T cell therapy
Immune tolerance

The transplant portfolio includes cellular immunotherapy and strategies aimed at supporting stable graft function.

Neurology, Psychiatry, and Post-Infectious Conditions

Clinical research also addresses post-COVID-19 syndrome, treatment-resistant depression, and posttraumatic stress disorder, reflecting interest in persistent neuropsychiatric and post-infectious syndromes.

Post-COVID-19 syndrome
Treatment-resistant depression
Posttraumatic stress disorder

These studies examine cognitive, emotional, and functional outcomes in difficult-to-treat patient groups.

Orthopedics and Musculoskeletal Repair

Musculoskeletal research includes osteoarthritis and proximal humeral fracture, with attention to joint degeneration, pain, and bone healing.

Knee osteoarthritis
Proximal humeral fracture

Additional work covers regenerative and local treatment approaches for orthopedic conditions.

Sponsored Trials

Trial Name	Country	Status
A Phase I/IIa open label single ascending dose study to assess safety and tolerability of regulatory T cells to promote discontinuation of tacrolimus monotherapy in liver transplant recipients - LiveTreg	Germany	Recruiting
Comparative Study of Atezolizumab, Carboplatin, and Nab-Paclitaxel Versus Pembrolizumab, Platinum, and Pemetrexed in Metastatic TTF-1 Negative Lung Adenocarcinoma	Germany	Not Recruiting
Comparison of B-cell Depletion by Rituximab and Anti-CD19 CAR-T Therapy in ACPA-Positive, Treatment-Refractory Rheumatoid Arthritis Patients	Germany	Recruiting
Efficacy and Safety Evaluation of Deucravacitinib in Adult Patients with Chronic Hand Eczema: A Randomized, Double-Blind, Placebo-Controlled Trial	Germany	Not Recruiting
Efficacy and Safety of Lebrikizumab in Adults With Moderate to Severe Localized Scleroderma: Randomized, Double-Blind, Placebo-Controlled Trial	Germany	Not Yet Recruiting
Efficacy and Safety of Tofacitinib in Early Active Axial Spondyloarthritis: A Randomized, Double-Blind, Placebo-Controlled Multicenter Study	Bulgaria Czechia Germany Poland	Not Recruiting
Efficacy of Imlifidase Combined with Standard of Care in Severe ANCA-Associated Vasculitis with Pulmonary Hemorrhage	Germany	Not Recruiting
Efficacy of Post-Resection Chemotherapy with Irinotecan, Fluorouracil, and Oxaliplatin in Metastatic Colorectal Cancer: A Phase III Randomized Trial	Germany	Recruiting
Evaluation of Abatacept and Daratumumab Combination Therapy in ACPA-Positive Rheumatoid Arthritis Patients	Germany	Recruiting
Evaluation of Anti-CD19 CAR-T Cell Therapy with KYV-101, Fludarabine Phosphate, and Cyclophosphamide Monohydrate in Refractory ANCA-IgG-Positive Vasculitis	Germany	Not Yet Recruiting