Clinical Research

Centre for Human Drug Research

Address
Zernikedreef 8

Sponsor Overview

assignment
11
sponsored trials
science
2
molecules
location_city
2
research centres
public
1
country
person_search
4
investigators

Specializations

Neuropathic pain and analgesic research

Clinical studies in chronic neuropathic pain, chronic pain, and neuropathic pain focus on pain relief, sensory profiling, and differences in treatment response across patient subgroups.

  • Chronic neuropathic pain
  • Quantitative sensory testing
  • Pain phenotyping
  • Analgesic effects

Research also includes evaluation of established pain medicines and experimental approaches to pain measurement in healthy volunteers and patients.

Cannabinoid and central nervous system studies

Trials examine cannabidiol and THC in relation to central nervous system function, including cognitive performance, neural excitability, and pain-related outcomes.

  • Cannabidiol
  • THC
  • CNS task performance
  • Transcranial magnetic stimulation

The research portfolio also covers interactions with other medicines used in pain and neurological settings.

Depression and neuropsychiatric assessment

Work in major depressive disorder includes studies of treatment-related effects on mood-related outcomes and neurobehavioral measures.

  • Major depressive disorder
  • Neuropsychiatric assessment
  • Ketamine
  • Antidepressant response

These studies connect psychiatric symptoms with measurable changes in brain function and clinical performance.

Cardiovascular, metabolic, and vascular research

Investigations in cardiovascular and metabolic diseases address vascular responses, microcirculation, and metabolic modulation in controlled clinical settings.

  • Cardiovascular and metabolic diseases
  • Vascular reactivity
  • Microvascular responses
  • Metabolic signaling

Related studies include assessments of inflammatory stimuli and their effects on blood vessel function.

Immunology and neuroimmune assessment

Research spans immuno-oncology assessments, immunological/cardiovascular conditions, and neuroimmune responses, with attention to inflammatory and physiological readouts.

  • Immuno-oncology assessments
  • Immunological responses
  • Inflammation
  • Neuroimmune interaction

These studies include evaluation of immune activation alongside pain, vascular, and neurological measures.

Sponsored Trials

Trial Name Country Status
A randomized, double-blind, placebo-controlled 2-way crossover study to assess the analgesic effects of THC in patients with chronic neuropathic pain and to phenotype the responders to THC treatment.The Netherlands The NetherlandsRecruiting
A Randomized, Double-Blind, Placebo-Controlled Study on Analgesic and CNS Effects of Morphine and Fluvoxamine in Chronic Pain in Healthy SubjectsThe Netherlands The NetherlandsNot Recruiting
A Study on the Pharmacokinetic Interactions of Cannabidiol, Amitriptyline, and Tramadol in Neurological AssessmentsThe Netherlands The NetherlandsNot Recruiting
Assessment of Pharmacodynamic Effects of an Authorized Compound and a Novel Agent on Nerve Excitability in Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled StudyThe Netherlands The NetherlandsNot Recruiting
Evaluation of Cannabidiol on Central Nervous System Function and Cortical Excitability in Healthy Males: A Randomized, Double-Blind, Placebo-Controlled Crossover StudyThe Netherlands The NetherlandsNot Recruiting
Evaluation of Imatinib Pharmacodynamics in Healthy Subjects for Immuno-Oncology AssessmentsThe Netherlands The NetherlandsNot Recruiting
Evaluation of Intradermal Lipopolysaccharide-Induced Vascular Responses in Patients with Immunological and Cardiovascular ConditionsThe Netherlands The NetherlandsNot Recruiting
Evaluation of Ketamine's Antidepressant Effects in Patients with Major Depressive DisorderThe Netherlands The NetherlandsNot Recruiting
Evaluation of Macro- and Microvascular Responses to Lipopolysaccharide and Exenatide in Cardiovascular and Metabolic Disease PatientsThe Netherlands The NetherlandsNot Recruiting
Evaluation of Nefopam and Oxycodone for Pain Assessment in Patients with Chronic PainThe Netherlands The NetherlandsNot Recruiting
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Data & Insights

science
Molecule Portfolio
Compounds under investigation
0
Exclusive Molecules
out of 2 total (0% not shared with other sponsors)

This sponsor works with 2 molecules, of which 0 are not being studied by other sponsors.

hub
Site Partnerships
Collaboration with research centres
50%
Return partnership rate
1 of 2 sites collaborated multiple times

This sponsor has worked with 2 sites across their trial portfolio.

Therapeutic Focus

  • 1.
    Nervous System Diseases4 trials
    449 other sponsors
  • 2.
    Mental Disorders2 trials
    150 other sponsors
  • 3.
    Not possible to specify2 trials
    220 other sponsors
  • 4.
    Cardiovascular Diseases1 trial
    359 other sponsors
  • 5.
    Investigative Techniques1 trial
    35 other sponsors
  • 6.
    Metabolism1 trial
    38 other sponsors

Partnered Research Centres

2 centres
location_city
assignment61
Academisch Ziekenhuis Leiden
Address
Albinusdreef 2, 2333 ZA Leiden
Learn morearrow_forward
location_city
assignment79
Centre for Human Drug Research
Address
Zernikedreef 8, 2333 CL Leiden
Learn morearrow_forward

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