AM-Pharma B.V.
- Address
- Stadsplateau 7
Sponsor Overview
Specializations
Hypophosphatasia and Bone Mineral Metabolism
Research activity includes adult hypophosphatasia, with attention to inorganic pyrophosphate and pyridoxal 5’-phosphate as biochemical markers linked to the disorder.
- Enzyme replacement in hypophosphatasia
- Biomarker changes in mineral metabolism
- Adult metabolic bone disease
The sponsor’s work in this area centers on ilofotase alfa in the context of alkaline phosphatase deficiency.
Renal Protection and Kidney Function
Clinical interest extends to renal damage associated with open heart surgery, with evaluation of interventions aimed at preserving renal function.
- Acute kidney injury prevention
- Postoperative renal impairment
- Cardiac surgery–related kidney risk
This area reflects an interest in protecting the kidneys in the setting of major cardiothoracic surgery.
Cardiothoracic Surgery and Perioperative Care
The sponsor funds research connected to cardiac surgery, especially clinical questions involving postoperative organ protection and recovery.
- Open heart surgery
- Perioperative organ protection
- Surgical complication prevention
These studies place emphasis on outcomes relevant to patients undergoing complex heart procedures.
Biochemical and Translational Medicine
Trial activity includes measurement of circulating biochemical signals associated with metabolic and renal conditions, supporting therapeutic development around targeted biologic intervention.
- Circulating biomarkers
- Metabolic disease monitoring
- Targeted biologic therapy
The research portfolio connects laboratory markers with clinically relevant endpoints in rare disease and surgical settings.
Sponsored Trials
| Trial Name | Country | Status |
|---|---|---|
| Evaluation of Ilofotase Alfa for Renal Protection in Patients at Risk of Renal Damage Post-Cardiac Surgery: A Double-Blind, Randomized, Placebo-Controlled Study |  Belgium Germany The Netherlands | Not Recruiting |
| Evaluation of Single-Dose Ilofotase Alfa in Adult Patients with Hypophosphatasia: A Pilot Study | Germany | Not Recruiting |
Data & Insights
This sponsor works with 1 molecule, of which 1 is not being studied by other sponsors.
This sponsor has worked with 11 sites across their trial portfolio.
Therapeutic Focus
- 1.Congenital, Hereditary, and Neonatal Diseases and Abnormalities1 trial165 other sponsors
- 2.Female Urogenital Diseases and Pregnancy Complications1 trial142 other sponsors
- 3.Male Urogenital Diseases1 trial111 other sponsors
Partnered Research Centres
11 centres- Address
- Deltalaan 1, 8800 Roeselare
- Address
- Meibergdreef 9, 1105 AZ Amsterdam
- Address
- Lazarettstrasse 36, Neuhausen-Nymphenburg, 80636 Munich
- Address
- Dr. Molewaterplein 40, 3015 GD Rotterdam
- Address
- Geert Grooteplein Zuid 10, 6525 GA Nijmegen
- Address
- Hufelandstrasse 55, Holsterhausen, 45147 Essen
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