Alpine Immune Sciences Inc.
- Address
- 188 East Blaine Street
Sponsor Overview
Specializations
Autoimmune Cytopenias
Clinical research in autoimmune cytopenias includes warm autoimmune hemolytic anemia (wAIHA), cold agglutinin disease (CAD), and immune thrombocytopenia (ITP), with attention to immune-mediated blood cell destruction and platelet loss.
- wAIHA
- CAD
- ITP
The sponsor’s work in this area is centered on povetacicept and its role in conditions driven by abnormal autoantibody activity and immune dysregulation.
Immunoglobulin A Nephropathy
Research in immunoglobulin A nephropathy focuses on kidney disease marked by proteinuria and progressive loss of renal function, reflecting a strong interest in glomerular disease.
- Proteinuria
- Renal function
- Glomerular disease
These studies examine povetacicept in adults with IgAN, highlighting a therapeutic focus on immune-driven kidney injury.
Immune-Mediated Disease Modulation
The sponsor’s clinical portfolio is concentrated on disorders in which B-cell and antibody-mediated pathways contribute to disease activity, spanning both hematologic and renal settings.
- B-cell pathway modulation
- Antibody-mediated disease
- Immune system regulation
This therapeutic area links autoimmune blood disorders with kidney inflammation through a shared immunologic mechanism.
Inflammatory and Renal Therapeutics
Clinical activity also extends to inflammatory disease and renal therapeutics, with emphasis on conditions where immune activation affects organ function and symptom burden.
- Inflammatory disease
- Renal therapeutics
- Organ-specific immune injury
The research landscape reflects interest in treatment strategies for hematologic autoimmunity and chronic kidney disease associated with immune pathology.
Sponsored Trials
| Trial Name | Country | Status |
|---|---|---|
| Evaluation of the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Povetacicept in Patients with Autoimmune Cytopenias: An Open-Label Study |  Austria Germany Italy Norway Spain | Not Recruiting |
| Phase 3 Randomized Double-Blind Placebo-Controlled Trial of Povetacicept in Adults with Immunoglobulin A Nephropathy | Austria Belgium Croatia Czechia Denmark Estonia Finland France Germany Hungary Ireland Italy Latvia Lithuania Norway Poland Spain Sweden The Netherlands | Not Recruiting |
Data & Insights
This sponsor works with 1 molecule, of which 0 are not being studied by other sponsors.
This sponsor has worked with 69 sites across their trial portfolio.
Therapeutic Focus
- 1.Female Urogenital Diseases and Pregnancy Complications1 trial142 other sponsors
- 2.Hemic and Lymphatic Diseases1 trial249 other sponsors
- 3.Immune System Diseases1 trial322 other sponsors
- 4.Male Urogenital Diseases1 trial111 other sponsors
Partnered Research Centres
69 centres- Address
- Moelleparkvej 4, 9000 Aalborg
- Address
- Deltalaan 1, 8800 Roeselare
- Address
- Avenida De Las Islas Baleares 3, 09006 Burgos
- Address
- 264 Rue Saint Pierre, 13005 Marseille
- Address
- Piazzale Giulio Cesare 11, 70124 Bari
- Address
- Corso Giuseppe Mazzini 18, 28100 Novara
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