ZorgSaam Ziekenhuis

At ZorgSaam Ziekenhuis in Terneuzen, clinical trials in Digestive System Diseases focus mainly on rectal cancer and metastatic colorectal cancer. The research is centered on improving survival and reducing recurrence, while also exploring whether treatment can be better tailored to individual risk.

• Adjuvant treatment strategies for rectal cancer with detectable ctDNA after surgery
• Therapy optimization for metastatic colorectal cancer, including approaches that balance effectiveness and tolerability

These studies aim to refine cancer care by testing whether more personalized treatment choices can improve outcomes for patients with advanced or high-risk disease.

The site conducts research in Neoplasms and Hormonal diseases with a strong emphasis on breast cancer, including HER2-positive breast cancer, HR+/HER2- metastatic breast cancer, and triple negative breast cancer. Trials also address treatment-related vasomotor symptoms in women receiving hormone therapy.

• Evaluating new ways to improve treatment effectiveness while reducing intensity in HER2-positive breast cancer
• Comparing treatment strategies for hormone receptor-positive metastatic breast cancer
• Studying symptom relief for moderate to severe hot flashes linked to breast cancer therapy
• Assessing added benefit of pembrolizumab in triple negative breast cancer with residual disease

Overall, this research aims to improve both cancer control and quality of life by testing better treatment combinations and supportive care options.

Clinical trials in Hemic and Lymphatic Diseases at this hospital include studies in chronic lymphocytic leukemia and multiple myeloma. The work is focused on finding more effective maintenance strategies, improving response depth, and understanding whether treatment breaks or sequence changes can still maintain disease control.

• Testing targeted treatment approaches for CLL, including patients whose disease has returned after earlier therapy
• Exploring whether venetoclax-based strategies can achieve deeper remission in relapsed CLL
• Studying treatment-free intervals and long-term disease control in multiple myeloma

These studies are designed to help define the best way to keep blood cancers under control while limiting unnecessary treatment burden.

In the area of Nervous System Diseases, the site is involved in trials for chronic or episodic migraine. This research is aimed at better preventing attacks and understanding how well longer-term treatment can be tolerated in everyday care.

• Preventive treatment research for migraine in people with chronic or episodic disease
• Assessment of long-term safety and tolerability of a new migraine therapy

The goal is to improve day-to-day migraine management for patients who need sustained symptom prevention.

Research in Respiratory Tract Diseases includes trials for advanced NSCLC. The main focus is on whether treatment intensity can be reduced without losing effectiveness, especially in patients receiving modern immunotherapy.

• Evaluating whether lower treatment exposure can remain effective in advanced non-small cell lung cancer
• Studying survival outcomes with adjusted use of pembrolizumab

This work reflects an effort to make lung cancer treatment more manageable while preserving the chance of good disease control.

The site also contributes to research in Cardiovascular Diseases, with a focus on venous thromboembolism prevention after major joint surgery. These studies examine how to better match clot prevention to a patient’s individual risk.

• Testing whether standard or intensified clot prevention is most effective after hip and knee replacement
• Studying safety and effectiveness of different approaches to prevent symptomatic VTE

This research aims to reduce the risk of serious blood clots while avoiding unnecessary bleeding complications.

Across several oncology studies, ZorgSaam Ziekenhuis is also involved in research that uses advanced diagnostic and treatment-guided approaches within Analytical, Diagnostic and Therapeutic Techniques and Equipment. These efforts support more precise decisions about when to intensify, reduce, or continue therapy.

• Using disease markers and imaging to guide treatment decisions in cancer care
• Exploring ways to personalize therapy based on response and risk

Such studies help move cancer treatment toward a more individualized model, where care is shaped by the patient’s disease behavior and treatment response.