University First multiprofile hospital for active treatment Sofia St. Joan Krastitel EAD

At the University First multiprofile hospital for active treatment Sofia St. Joan Krastitel EAD, research in respiratory diseases and infectious diseases focuses on improving care for people with asthma, chronic obstructive pulmonary disease, and diabetic foot infections. These studies are exploring new treatment options, long-term safety, and better control of symptoms and inflammation.

• Studies in asthma are evaluating ways to improve control and reduce daily treatment needs.
• Research in COPD is examining long-term safety and symptom management for patients with persistent disease.
• Trials in diabetic foot infections are assessing new antibacterial treatment approaches and safety.

Overall, this area combines treatment optimization with efforts to improve patient outcomes in chronic airway disease and serious infections.

The site also supports research in neurology, with trials involving multiple sclerosis, Parkinson's disease, migraine, epilepsy, and acute ischemic stroke. These studies aim to improve long-term disease control, address symptoms that affect daily life, and test therapies that may support recovery or prevention.

• Multiple sclerosis studies are looking at long-term treatment safety and the patient experience of living with the disease.
• Parkinson's disease research is focused on safety, tolerability, and symptoms such as apathy.
• Migraine and epilepsy trials are evaluating new options to reduce attacks and seizures.
• Stroke research is testing treatments intended to improve recovery after an acute event.

These projects reflect a strong interest in both symptom relief and longer-term neurological care.

In ophthalmology, the clinic is involved in studies for diabetic macular edema and vernal keratoconjunctivitis. The research is centered on comparing treatment effectiveness and finding better ways to protect vision and reduce inflammation in eye disease.

• Diabetic macular edema trials are assessing whether a new eye treatment can match established care.
• Vernal keratoconjunctivitis research is comparing therapies for moderate to severe allergic eye inflammation.

These studies aim to support better visual outcomes and more comfortable day-to-day eye care for patients.

Research in cardiovascular disease at this hospital in Sofia includes work related to acute ischemic stroke, with a focus on treatment effectiveness and recovery after delayed presentation. The goal is to improve outcomes for patients who may still benefit from therapy even after the earliest treatment window.

• Acute ischemic stroke studies are testing whether treatment can improve functional recovery.
• The research is aimed at expanding options for patients with salvageable brain tissue after stroke.

This area emphasizes better recovery, stronger functional outcomes, and more flexible acute stroke care.

Clinical research in musculoskeletal disease is represented through studies that address inflammatory and chronic conditions affecting mobility and daily function. At this site, the broader focus is on evaluating therapies that may improve symptom control and quality of life in patients with complex long-term illness.

• Trials in this area are centered on treatment effectiveness and ongoing symptom relief.
• The work supports better management of chronic conditions that can affect movement and comfort.

Although the disease mix is broad, the research theme remains consistent: finding practical treatments that help patients function better in everyday life.

The Clinic of Endoscopy and Surgery contributes to a diverse clinical trial portfolio spanning several major therapeutic areas. The studies bring together respiratory, neurological, eye, cardiovascular, infectious, and musculoskeletal research, reflecting a wide-ranging effort to test new therapies, compare established treatments, and improve long-term disease management.

• Testing new or improved therapies for chronic diseases.
• Evaluating safety and tolerability over longer periods of care.
• Comparing current treatments to identify more effective options.

With 18 trials and 7 investigators, the site shows active involvement in clinical research that addresses both common and complex conditions.