Universitaetsklinikum Giessen und Marburg GmbH

At Universitaetsklinikum Giessen und Marburg GmbH, the Klinik für Augenheilkunde is running clinical trials focused on eye diseases and related visual disorders. The research includes studies in retinal vein occlusion, age-related macular degeneration, and thyroid eye disease, with the aim of improving sight, protecting retinal function, and evaluating new treatment options.

• Macular edema secondary to retinal vein occlusion
• Geographic atrophy secondary to age-related macular degeneration
• Thyroid eye disease

This work reflects a strong interest in both diagnostic and therapeutic advances for conditions that can significantly affect daily vision and quality of life.

A major part of the research portfolio at this site addresses neoplasms across several cancer types, with trials designed to test new combinations, compare treatment strategies, and improve outcomes after surgery or in advanced disease. The studies span solid tumors and blood cancers, including cancers of the liver, stomach, lung, breast, ovary, pancreas, prostate, and skin.

• Breast cancer
• Hepatocellular carcinoma
• Gastric and gastroesophageal junction adenocarcinoma
• Non-squamous non-small cell lung cancer
• Multiple myeloma
• Chronic myeloid leukemia

The overall goal is to evaluate new cancer therapies, refine adjuvant and maintenance treatment, and identify approaches that may better control advanced or high-risk disease.

The site also supports extensive clinical research in nervous system diseases, especially disorders that affect movement, cognition, and seizure control. Trials are studying Parkinson’s disease, epilepsy, and dementia, with a focus on slowing progression, reducing seizure burden, and improving long-term neurologic outcomes.

• Parkinson’s disease
• Focal epilepsy and focal onset seizures
• Established status epilepticus
• Alzheimer-related and vascular dementias
• Delayed sleep-wake phase disorder

These studies are aimed at testing new neurologic treatments, supporting symptom control, and generating better evidence for care in both acute and chronic brain disorders.

Clinical trials at this center include a broad range of immune system diseases, with notable activity in allergic disease, urticaria, and autoimmune skin conditions. The research is designed to relieve persistent symptoms, reduce flare-ups, and assess targeted therapies for immune-driven disorders.

• Chronic spontaneous urticaria
• Chronic inducible urticaria
• Birch pollen-induced allergic rhinoconjunctivitis
• Bullous pemphigoid
• Actinic keratosis

In this area, the emphasis is on improving disease control and testing treatments that may offer better relief for patients with difficult-to-manage inflammatory conditions.

Research at the site also covers respiratory tract diseases and related supportive care questions, including trials in chronic obstructive pulmonary disease, viral lung infection, sleep disorders, and neonatal lung health. These studies aim to improve breathing outcomes, sleep quality, and early-life respiratory support.

• Chronic obstructive pulmonary disease
• Severe viral lung infections
• Delayed sleep-wake phase disorder
• Sleep disturbances associated with menopause
• Respiratory distress syndrome in preterm infants

The research is centered on testing supportive treatments and evaluating whether they can improve symptoms, recovery, and longer-term health.

Another important research stream includes studies in pathological conditions such as chronic pain and blood pressure disorders, along with diseases of the digestive system. Trials are exploring better symptom relief for neuropathic and back pain, improved control of difficult-to-treat hypertension, and more effective treatment strategies for gastrointestinal cancers and pancreatic disease.

• Chronic pain due to diabetic polyneuropathy
• Chronic pain due to traumatic or post-operative peripheral neuropathy
• Chronic back pain
• Resistant and uncontrolled hypertension
• Resected pancreatic ductal adenocarcinoma
• Advanced gastroesophageal and pancreatic cancers

At Universitaetsklinikum Giessen und Marburg GmbH, these studies are intended to evaluate treatment effectiveness and support better day-to-day functioning for patients with complex chronic conditions.