Unidade Local De Saude De Gaia/Espinho E.P.E.

At Unidade Local De Saude De Gaia/Espinho E.P.E., a strong cardiovascular and cerebrovascular research program is exploring major conditions such as atrial fibrillation, acute coronary syndrome, heart failure, aortic stenosis, and stroke. These studies are mainly designed to test new ways to prevent events, improve symptom control, and reduce long-term complications.

• Research on atrial fibrillation and prevention of embolic events
• Studies in heart attack, atherosclerotic cardiovascular disease, and high cardiovascular risk
• Trials in aortic valve stenosis and treatment after transcatheter aortic valve implantation
• Investigations in acute ischemic stroke and urgent reversal of anticoagulation

Work in this area reflects a broad effort to improve prevention and treatment for people with common and high-impact heart and brain vascular diseases.

The site has extensive activity in oncology and hematology, studying cancers such as breast cancer, non-small cell lung cancer, head and neck squamous cell carcinoma, bladder cancer, colorectal cancer, multiple myeloma, and lymphoma. Many trials focus on evaluating new treatments, improving disease control, and extending remission in both early and advanced disease.

• Studies in breast neoplasms, including recurrence prevention and advanced disease
• Trials in lung cancer and EGFR-mutated NSCLC after prior treatment
• Research in multiple myeloma and lymphomas to improve response rates
• Programs in bladder cancer and head and neck cancer exploring new therapeutic options

This oncology portfolio shows a clear interest in both targeted therapies and combination approaches across solid tumors and blood cancers.

Immune-mediated disease is another major focus at the Unit of Phase 1, with trials in systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, Sjögren’s disease, psoriatic arthritis, and systemic sclerosis. These studies are aimed at better controlling inflammation, protecting organ function, and improving day-to-day symptoms.

• Research in systemic lupus erythematosus and lupus nephritis
• Studies in rheumatoid arthritis, psoriatic arthritis, and juvenile psoriatic arthritis
• Trials in Sjögren’s syndrome and systemic sclerosis
• Investigations in other immune system diseases to improve disease control

These projects highlight ongoing efforts to refine treatment for chronic inflammatory disorders that can affect multiple organs and quality of life.

Clinical trials at Unidade Local De Saude De Gaia/Espinho E.P.E. also cover important renal and urologic conditions such as IgA nephropathy, focal segmental glomerulosclerosis, chronic kidney disease, bladder cancer, and urothelial carcinoma. The main goal is to evaluate therapies that may slow disease progression, protect kidney function, and improve cancer outcomes.

• Studies in IgA nephropathy and focal segmental glomerulosclerosis
• Research in lupus nephritis and other kidney-related immune diseases
• Trials in non-muscle-invasive bladder cancer and urothelial cancer
• Work aimed at preserving renal function and improving urinary tract cancer care

This area combines nephrology and oncology, reflecting a broad interest in diseases that often require long-term, specialized management.

The site is active in respiratory research, including idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, pulmonary arterial hypertension, chronic obstructive pulmonary disease, and bronchiectasis. These studies are generally intended to assess new treatments that may slow disease progression, improve breathing, and support long-term lung health.

• Trials in idiopathic pulmonary fibrosis and broader pulmonary fibrosis
• Research in pulmonary arterial hypertension
• Studies in COPD and bronchiectasis
• Evaluation of therapies for chronic lung disease and symptom relief

These programs show a strong commitment to chronic lung disorders where better disease control can make a major difference in daily function.

Research in metabolic, endocrine, and liver disease includes type 2 diabetes, type 1 diabetes, obesity, non-alcoholic steatohepatitis, hypertriglyceridemia, and hypoparathyroidism. The trials are focused on improving metabolic control, preventing complications, and exploring new options for chronic disease management.

• Studies in type 2 diabetes and type 1 diabetes
• Research on obesity and related cardiometabolic risk
• Trials in non-alcoholic steatohepatitis and severe hypertriglyceridemia
• Work in hypoparathyroidism and other hormone-related conditions

This portfolio reflects a practical focus on common chronic illnesses that often overlap and require coordinated care.

The research portfolio also includes neurology, eye disease, and mental health, with studies in generalized myasthenia gravis, acute ischemic stroke, thyroid eye disease, age-related macular degeneration, and schizophrenia. These trials are intended to improve symptom management, preserve function, and evaluate new approaches to treatment.

• Studies in generalized myasthenia gravis and other immune-related neurologic disorders
• Trials in thyroid eye disease and macular degeneration
• Research in stroke recovery and acute treatment support
• Investigations in schizophrenia to assess better long-term disease control

At this site in Vila Nova de Gaia, these studies underline a broad interest in disorders that can strongly affect independence, vision, and quality of life.