Synexus Polska Sp. z o.o.

At Synexus Polska Sp. z o.o. in Gdansk, a large share of the research focuses on skin and connective tissue diseases and immune system diseases, especially atopic dermatitis, plaque psoriasis, prurigo nodularis, vitiligo, and urticaria. These studies are mainly designed to test new treatments and better understand how well they control symptoms over time.

• Moderate to severe atopic dermatitis, with trials aimed at improving symptom control and long-term disease management
• Plaque psoriasis and psoriatic arthritis, including studies evaluating new options for reducing skin inflammation and joint symptoms
• Chronic spontaneous urticaria, cold-induced urticaria, and symptomatic dermographism, focusing on better relief of recurring hives and itching
• Vitiligo and prurigo nodularis, with research centered on new therapies for difficult-to-treat skin conditions

This area reflects a strong dermatology program at the site, with frequent work on both short-term symptom improvement and longer-term safety.

The site also conducts substantial research in digestive system diseases and related physiological processes, particularly Crohn’s disease, ulcerative colitis, eosinophilic esophagitis, and erosive esophagitis. Several trials also address NASH and MASH, showing a clear interest in both inflammatory bowel disease and progressive liver conditions.

• Crohn’s disease and ulcerative colitis, with studies evaluating treatments that may improve remission and digestive health
• Eosinophilic esophagitis and erosive esophagitis, focused on easing swallowing-related and reflux-related symptoms
• NASH and MASH, including research aimed at resolving liver inflammation and slowing fibrosis
• Broader digestive system disorders, supporting new approaches to chronic gastrointestinal care

These trials are designed to assess both effectiveness and durability of response in chronic conditions that often require long-term management.

Another important theme at Synexus Polska Sp. z o.o. is cardiovascular disease and nutritional and metabolic diseases, including hypertension, obesity, type 2 diabetes mellitus, and high cardiovascular risk conditions. The research in this area mainly explores whether new therapies can reduce major health events and improve long-term metabolic control.

• Hypertension and established cardiovascular disease, with trials focused on lowering cardiovascular risk
• Obesity and type 2 diabetes, including studies looking at weight and blood sugar control
• Transthyretin amyloidosis with cardiomyopathy, aimed at improving outcomes in a serious heart condition
• Cardiometabolic prevention studies, designed to help reduce the chance of heart attack, stroke, and related events

This field combines prevention and treatment research, with an emphasis on long-term benefit for people living with chronic metabolic and heart-related illness.

The site contributes to musculoskeletal diseases research as well, including rheumatoid arthritis, active psoriatic arthritis, chronic low back pain, and postmenopausal osteoporosis. These studies are generally aimed at easing pain, preserving mobility, and improving bone and joint health.

• Rheumatoid arthritis and psoriatic arthritis, with research focused on reducing inflammation and joint damage
• Chronic non-specific low back pain, exploring better options for persistent pain relief
• Postmenopausal osteoporosis, with trials assessing ways to protect bone strength
• Musculoskeletal symptom studies, supporting improved daily function and quality of life

The research portfolio in this area reflects a strong interest in both symptom control and prevention of long-term disability.

Gdansk-based research at this site also includes respiratory tract diseases and virus diseases, with studies in asthma, respiratory syncytial virus infections, and recurrent herpes labialis, as well as work on bacterial prevention. These trials generally aim to improve protection, symptom control, or treatment effectiveness.

• Moderate to severe uncontrolled asthma, with studies testing new ways to improve breathing control
• Respiratory syncytial virus research, focused on immune response and prevention
• Recurrent herpes labialis, evaluating treatments for cold sore outbreaks
• Bacterial infection prevention, including studies designed to reduce the risk of invasive disease

This mix of trials shows activity across both chronic respiratory care and infectious disease prevention.

The research portfolio also includes studies that bridge metabolic disease, ophthalmology, and long-term safety monitoring, such as work on diabetic retinopathy in people with type 2 diabetes. In addition, some trials are designed to confirm ongoing safety and effectiveness of treatments already in use or under extended observation.

• Diabetic retinopathy, with research aimed at understanding eye disease progression in diabetes
• Long-term safety studies, supporting continued evaluation of treatment tolerability over time
• Ongoing effectiveness research, helping determine whether benefits remain stable in real-world use
• Cross-specialty studies, linking metabolic control with eye and vascular outcomes

This area highlights the site’s role in follow-up research that helps clarify both benefit and safety in chronic disease care.