Siteworks GmbH

At Siteworks GmbH in Hanover, a strong share of the research focuses on respiratory tract diseases and sleep-related conditions. The studies include asthma, chronic obstructive pulmonary disease, refractory chronic cough, and obstructive sleep apnea, with the aim of improving symptom control, lung function, breathing-related outcomes, and overall quality of life.

• Testing new approaches for inadequately controlled asthma and severe asthma
• Evaluating treatments for COPD and reducing exacerbations
• Studying therapies for obstructive sleep apnea linked to overweight or obesity
• Assessing options for chronic cough and nasal allergy symptoms

This area of research is centered on finding better ways to manage long-term breathing disorders and sleep disturbances.

Another major theme at the site is the study of pain disorders, musculoskeletal diseases, and nutritional and metabolic diseases. Trials are looking at diabetic peripheral neuropathic pain, knee osteoarthritis, chronic low back pain, hypercholesterolemia, obesity, and related conditions, with the goal of easing pain, supporting mobility, and improving metabolic health.

• Exploring new therapies for neuropathic pain and osteoarthritis
• Evaluating treatments for overweight and obesity with related health risks
• Studying options that may improve cholesterol and cardiovascular risk factors
• Assessing relief strategies for chronic back pain and joint pain

The research reflects a broader effort to address conditions that commonly affect daily function and long-term health.

The site also conducts trials in cardiovascular diseases and kidney-related conditions, especially where blood pressure control and heart protection are important. Current research includes uncontrolled hypertension, resistant hypertension, chronic kidney disease, and prevention of heart failure, with studies designed to evaluate better treatment effectiveness and long-term outcomes.

• Investigating therapies for high blood pressure that remains difficult to control
• Assessing approaches for chronic kidney disease linked with hypertension
• Studying prevention of heart failure and cardiovascular complications
• Comparing treatments to improve LDL cholesterol and cardiovascular risk

These studies aim to support better management of conditions that can lead to serious heart and kidney complications.

A notable part of the portfolio addresses skin and connective tissue diseases and immune system diseases. Research at the site includes atopic dermatitis, plaque psoriasis, chronic spontaneous urticaria, perennial allergic rhinitis, and female androgenetic alopecia, focusing on symptom reduction, disease control, and improved patient comfort.

• Testing new treatments for psoriasis and atopic dermatitis
• Evaluating therapies for urticaria and allergic rhinitis
• Studying options for hair loss in women
• Assessing immune-targeted therapies for persistent inflammatory conditions

This work reflects a strong interest in conditions driven by inflammation, allergy, and immune dysregulation.

The remaining studies cover digestive system diseases, hormonal diseases, and mental disorders. Trials include irritable bowel syndrome, diarrhoea-predominant IBS, sleep disturbances associated with menopause, insomnia disorder, and major depressive disorder, with the purpose of improving symptoms, supporting sleep, and evaluating overall treatment benefit.

• Assessing therapies for IBS and diarrhoea-predominant IBS
• Studying treatments for menopause-related sleep problems and insomnia
• Evaluating options for mild to moderate depression
• Testing supportive approaches for digestive comfort and symptom relief

Together, these studies show a broad interest in conditions that affect sleep, mood, and gastrointestinal health.

Virus diseases are represented through research on influenza, where the focus is on preventive care and protection against infection. These studies are designed to assess vaccine effectiveness and safety, contributing to better seasonal disease prevention.

• Evaluating an influenza vaccine for protection against common viral strains
• Studying safety and immune response in preventive research

This adds a public-health-oriented dimension to the broader clinical trial program at the site.