Multi-profile Hospital for Active Treatment Heart and Brain EAD

The Multi-profile Hospital for Active Treatment Heart and Brain EAD is conducting studies on atherosclerotic cardiovascular disease, heart failure across ejection‑fraction categories, and the interplay between chronic kidney disease and systemic inflammation. Trials aim to test new anti‑inflammatory agents, lipid‑lowering therapies, and combination treatments that could reduce major adverse cardiovascular events.

• Atherosclerotic disease risk reduction
• Heart failure with reduced or preserved ejection fraction
• Acute myocardial infarction early intervention
• Chronic kidney disease and cardiovascular outcomes
• Inflammation‑targeted therapies
• Lipid‑lowering and LDL‑C management

Researchers at the Pleven site collaborate with regional cardiology networks to accelerate access to novel therapies for patients with high cardiovascular risk.

Investigations focus on severe and eosinophilic asthma, chronic obstructive pulmonary disease, and acute viral lung infections. The goal is to evaluate inhaled combination therapies, biologic agents, and novel anti‑viral strategies that improve lung function and reduce exacerbations.

• Severe asthma control with biologics
• Triple inhaler therapy versus dual bronchodilator regimens
• COPD exacerbation prevention
• Eosinophilic asthma add‑on treatment
• Viral lung infection adjunctive therapy
• Biomarker‑guided dosing strategies

The department leverages its pulmonary expertise to bring cutting‑edge respiratory medicines to the Bulgarian patient community.

The centre is active in trials addressing acute ischemic stroke, multiple sclerosis subtypes, Parkinson’s disease, and seizure disorders. Studies evaluate early reperfusion agents, disease‑modifying therapies for relapsing and progressive MS, and safety of novel compounds for movement disorders.

• Acute stroke functional outcome improvement
• Relapsing multiple sclerosis relapse delay
• Progressive multiple sclerosis brain atrophy reduction
• Parkinson’s disease long‑term safety
• Seizure control with new anticonvulsants
• Neuroimaging biomarkers for disease activity

Collaboration with neurology specialists ensures rigorous assessment of neurological interventions at the hospital.

A portfolio of cancer studies includes non‑small cell lung cancer, HER2‑negative advanced breast cancer, and advanced prostate cancer. The research evaluates targeted therapies, immunotherapy combinations, and sequencing strategies to improve survival and quality of life for oncology patients.

• Advanced NSCLC with targeted agents
• HER2‑negative breast cancer combination therapy
• Prostate cancer monoclonal antibody trials
• Immunotherapy plus chemotherapy sequencing
• Neoadjuvant treatments for resectable lung cancer
• Biomarker‑driven patient selection

The hospital’s oncology unit partners with national cancer networks to bring innovative cancer treatments to patients in Bulgaria.

Clinical work extends to insomnia disorder in children and adolescents, as well as behavioral health interventions. Trials assess dose‑response relationships of novel hypnotics, objective sleep measures, and behavioral discipline programs to enhance mental health outcomes.

• Pediatric insomnia pharmacotherapy
• Objective total sleep time measurement
• Behavioral discipline effectiveness
• Safety of long‑term hypnotic use
• Integration of sleep therapy with mental health care
• Quality‑of‑life assessments in sleep disorders

The multidisciplinary team integrates psychiatric expertise with sleep medicine to address complex behavioral health needs.

Research also covers analytical diagnostics, advanced imaging, and surgical technique evaluation. Projects aim to validate new biomarkers, improve point‑of‑care testing, and refine minimally invasive procedures for cardiovascular and neurological conditions.

• High‑sensitivity C‑reactive protein biomarker validation
• Quantitative MRI for brain atrophy in MS
• Point‑of‑care diagnostic device testing
• Minimally invasive cardiac surgery assessment
• Real‑time imaging guidance for stroke interventions
• Equipment performance in therapeutic settings

By integrating cutting‑edge technology, the hospital supports accurate diagnosis and effective treatment across its therapeutic areas.