Maxima Medisch Centrum
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Analytical, Diagnostic and Therapeutic Techniques and Equipment – Anesthesia and Analgesia
At Maxima Medisch Centrum, researchers are advancing pain management strategies by testing new regional anesthesia techniques and multimodal analgesic protocols to improve patient comfort during procedures.
- Development of ultrasound‑guided nerve blocks
- Evaluation of multimodal analgesia regimens
- Assessment of patient‑reported pain outcomes
- Safety studies of novel anesthetic agents
- Implementation of opioid‑sparing approaches
With 28 active trials and 41 investigators, the program emphasizes reducing opioid reliance while maintaining effective peri‑operative care.
Analytical, Diagnostic and Therapeutic Techniques and Equipment – Therapeutics
The department focuses on innovative therapeutic devices and drug‑delivery systems to enhance treatment efficacy for chronic cardiac and metabolic conditions.
- Development of implantable cardiac monitoring systems
- Evaluation of targeted drug‑delivery platforms
- Studies on wearable health technology
- Optimization of infusion pump technologies
- Validation of tele‑monitoring solutions for heart failure
Collaborative engineering partnerships support rapid translation of prototypes into clinical practice.
Analytical, Diagnostic and Therapeutic Techniques and Equipment – Surgical Procedures, Operative
Surgeons are investigating minimally invasive surgery and enhanced recovery pathways to shorten hospital stays and improve outcomes for abdominal and cardiac operations.
- Laparoscopic approaches for colorectal disease
- Robotic assistance in cardiac procedures
- Peri‑operative antibiotic lavage studies after appendectomy
- Evaluation of enhanced recovery after surgery (ERAS) protocols
- Comparative trials of operative versus non‑operative management of appendicitis
The surgical team works closely with anesthesia and intensive care to streamline patient pathways.
Diseases – Cardiovascular Diseases
Cardiovascular research targets a spectrum from atherosclerosis to heart failure, testing new drugs and lifestyle interventions to lower major adverse cardiac events.
- Trials on lipid‑lowering therapies for elevated Lp(a)
- Evaluation of novel anti‑arrhythmic agents for atrial fibrillation
- Studies on heart failure with preserved ejection fraction (HFpEF)
- Investigation of anti‑inflammatory treatments for atherosclerotic disease
- Assessment of cardio‑protective outcomes after surgical interventions
The cardiology unit leverages a large patient cohort to generate robust data on risk reduction.
Diseases – Congenital, Hereditary, and Neonatal Diseases and Abnormalities
The center conducts research on early‑life conditions, aiming to improve neonatal outcomes and prevent pregnancy‑related complications.
- Evaluation of metformin for preterm preeclampsia
- Allopurinol combined with therapeutic hypothermia for hypoxic‑ischemic encephalopathy
- Research on hormonal influences in congenital heart defects
- Assessment of maternal‑fetal monitoring technologies
- Trials on early interventions for hereditary metabolic disorders
Multidisciplinary teams of obstetrics, neonatology, and genetics provide comprehensive care for mother‑infant dyads.
Diseases – Digestive System Diseases
Investigations address colorectal cancer and liver metastases, refining chemotherapy regimens and surgical timing to improve disease control.
- Induction chemotherapy for locally advanced rectal cancer
- Hepatic arterial infusion pump studies for unresectable liver metastases
- Dose‑reduced chemotherapy in older colorectal cancer patients
- Antibiotic lavage after appendectomy to prevent intra‑abdominal abscess
- Metabolic modulation trials for functional gastrointestinal disorders
Gastroenterology and surgery collaborate to align systemic and local therapies for optimal outcomes.
Diseases – Female Urogenital Diseases and Pregnancy Complications
Research focuses on uterine fibroids, contraceptive innovations, and pregnancy‑related hypertension to enhance safety and quality of life.
- Non‑surgical management of fibroids with ulipristal
- Nonavalent HPV vaccine efficacy for vulvar HSIL
- Contraception trials using weekly mifepristone
- Metformin for prolonging gestation in preterm preeclampsia
- Assessment of hormonal therapy impacts on reproductive health
Patient‑centered outcomes such as symptom severity and fertility preservation guide study designs.
Diseases – Hormonal diseases
Hormonal research includes studies on polycystic ovary syndrome, late‑onset hypogonadism, and metabolic endocrine disorders, testing hormonal modulation and lifestyle strategies.
- Testosterone replacement outcomes after prostatectomy
- Ovulation induction with letrozole versus gonadotropins
- Treatment efficacy for late‑onset hypogonadism
- Hormonal regulation studies in obesity
- Adherence to endocrine therapy in breast cancer
Endocrinology collaborates with reproductive specialists to tailor individualized interventions.
Diseases – Neoplasms
Oncology trials span breast, lung, melanoma, and multiple myeloma, evaluating novel immunotherapy combinations and targeted agents to improve survival rates.
- Combination immunotherapy for metastatic non‑small cell lung cancer
- Palbociclib added to endocrine therapy in early breast cancer
- Novel agents for relapsed multiple myeloma
- Adjuvant therapy trials for stage III melanoma
- Comparative studies of chemotherapy versus immunotherapy in squamous NSCLC
The cancer center integrates translational research to match molecular profiles with therapeutic options.
Diseases – Nutritional and Metabolic Diseases
Metabolic studies target obesity and elevated lipoprotein(a), assessing novel agents that modify lipid pathways and reduce cardiovascular risk.
- Lepodisiran for Lp(a) reduction
- Orforglipron impact on cardiovascular outcomes
- Muvalaplin evaluation for major cardiovascular events
- Semaglutide use in atrial fibrillation patients with obesity
- Weight‑loss intervention trials and metabolic effects
Nutritionists and cardiologists work together to address the intersection of metabolism and heart health.
Diseases – Virus Diseases
Viral disease research includes the evaluation of HPV vaccination strategies and management of virus‑related cancers to reduce infection‑driven malignancies.
- Nonavalent HPV vaccine for vulvar HSIL prevention
- Antiviral strategies in virus‑associated cancers
- Immune response assessment to viral antigens in oncology
- Vaccine uptake studies in high‑risk populations
- Management of viral infections in immunocompromised patients
Public‑health outreach programs support education on vaccination benefits.
Health Care – Environment and Public Health
The site examines how environmental exposures influence disease prevalence, focusing on interventions that improve population public health policies.
- Impact of air pollution on atherosclerotic disease incidence
- Community‑based lifestyle intervention studies
- Health‑care resource utilization analyses in chronic disease
- Environmental exposure effects on pregnancy outcomes
- Cost‑effectiveness of preventive public‑health programs
Partnerships with municipal health agencies enable large‑scale population research.
Health Care – Health Care Economics and Organizations
Economic analyses assess the cost‑effectiveness of innovative therapies and organizational models to optimize patient pathways and resource allocation.
- Budget impact of novel heart‑failure medications
- Economic evaluation of minimally invasive surgical techniques
- Health‑technology assessment of diagnostic equipment
- Comparative analysis of inpatient versus outpatient management
- Modeling long‑term outcomes for oncology treatments
Health economists collaborate with clinicians to inform reimbursement and policy decisions.
Phenomena and Processes – Reproductive and Urinary Physiological Phenomena
Studies explore the physiology of reproductive and urinary systems, aiming to improve diagnostics for conditions such as urolithiasis and PCOS.
- Biomarker discovery for urinary stone formation
- Hormonal profiling in polycystic ovary syndrome
- Evaluation of renal colic pain‑management techniques
- Investigation of urinary tract infection recurrence patterns
- Research on reproductive hormone cycles and fertility outcomes
Collaboration with laboratory medicine enhances translational insights into reproductive and urinary health.
Site Overview
Activity Indicator
Last 6 months
Trial Flow
How this site's trials are distributed across therapeutic areas and active substances (IMPs), and how they're positioned within their overall lifecycle status. Flow thickness represents the number of unique trials.
Top 4 of 21 therapeutic areas and 15 of 182 IMPs, ranked by number of trials.
Compounds & Molecules Timeline
The time span of clinical-trial activity for the main active substances (IMPs) studied at this site over the last 8 years. Each bar runs from the earliest trial start to the most recent end; a substance with a trial still open has no recorded end and is shown as ongoing.
Top 40 of 180 compounds, ranked by number of trials.
Sponsor & Partnership
Top sponsors by active trials, and the ones that have come back for more than one study.
Sponsor Network
Top 22 by active trials.
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Partnership History
Sponsors with repeated collaboration (≥ 2 trials).
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Sponsor Network Graph
How sponsors and therapeutic areas connect across this site's active trials: each link is at least one active trial shared between them, and bigger nodes mean more activity. Click a node to see its exact connections.
Country Benchmark
Compared to 271 other sites in The Netherlands
Therapeutic Area Benchmark — The Netherlands
Select a therapeutic area to compare against other sites in The Netherlands.
Competitor Comparison
Similar sites in the same country running a comparable number of trials (within ±30%), scored on how closely their trial portfolios match this one. Higher percentages mean a more similar profile.
Country: The Netherlands
Market Share
Country: The Netherlands
Therapeutic Area Market Share
Select a therapeutic area to view its disease coverage breakdown.
Heat Maps & Advanced Analytics
How often specific conditions appear in trials across this site and comparable sites from the same country. Each row is a site, each column a condition, and each cell the number of trials on it — darker means more activity.
Other Trials in Maxima Medisch Centrum
lock Showing 1 of 80 trials — the rest is available on a paid plan.
| Trial | Sponsor | Phase | Status | Start Date | End Date |
|---|---|---|---|---|---|
| A Phase 2/3, multicenter, randomized open-label study of zanzalintinib vs everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors | Exelixis Inc. | Phase IV | Recruiting | Jan 2026 | — |
IMP list
lock Showing 1 of 182 compounds — the rest is available on a paid plan.
| IMP | Trials | Status | First start | Last start |
|---|---|---|---|---|
| Nivolumab | 8 | Unknown | 2016-07-25 | 2024-12-18 |
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