Karolinska Institutet
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Oncology and Hematologic Diseases
At Karolinska Institutet, clinical research in neoplasms and blood-related conditions focuses on people living with advanced cancers and those who have received cellular therapies. These studies are designed to support continued treatment, monitor safety, and evaluate how well new or ongoing cancer approaches help patients maintain disease control.
- Advanced malignancies and other difficult-to-treat cancer conditions
- Maintenance treatment for advanced ovarian cancer
- Long-term follow-up after CAR T-cell therapy
Overall, the work aims to improve treatment durability, track delayed side effects, and refine care for patients with complex cancer histories.
Nervous System Diseases and Eye Diseases
This research area covers both brain and vision disorders, with studies exploring new ways to diagnose and treat conditions such as Alzheimer's disease, Parkinson's disease, Dementia with Lewy Bodies, Multiple System Atrophy, and central retinal artery occlusion. The trials often focus on imaging, early detection, and testing therapies that may protect neurological or visual function.
- Alzheimer's disease and related cognitive decline
- Parkinson's disease and suspected alpha-synuclein pathology
- Central retinal artery occlusion and urgent vision-saving treatment
These studies combine treatment evaluation with advanced brain and eye imaging to better understand disease processes and improve diagnosis.
Psychiatry and Psychology and Behavioral Research
Clinical trials here also examine behavior, substance use, and related brain processes. The site investigates how interventions may influence alcohol use disorder, social behavior, and brain function, with a broader goal of improving understanding of mental health and behavior-related conditions.
- Alcohol Use Disorder and high alcohol use
- Prosocial behavior and behavioral change
- Brain mechanisms linked to addiction and decision-making
These studies are aimed at identifying better strategies for prevention, support, and treatment in behavioral health.
Immune System Diseases, Endocrine-Related Disorders, and Musculoskeletal Diseases
Research at this site also includes immune-mediated and metabolic conditions, along with disorders affecting the jaw muscles. Investigators are studying how immune-based treatments may influence latent autoimmune diabetes in adults, while other work looks at symptom relief and biological changes in myogenous temporomandibular disorders.
- Latent Autoimmune Diabetes in Adults (LADA)
- Myogenous temporomandibular disorders
- Immune and metabolic responses after treatment
These trials seek to clarify treatment effects, improve disease monitoring, and better understand how targeted interventions alter underlying biology.
Imaging and Healthy Volunteer Research
Several studies at Department of Clinical Neuroscience involve healthy volunteers to support the development of new imaging tools and to compare results with patients who have neurological disease. This work helps assess how well potential brain-tracing methods can detect disease-related proteins and support future diagnostic advances.
- Brain imaging in healthy volunteers
- Evaluation of new PET tracers for alpha-synuclein and related targets
- Comparisons between healthy participants and patients with cognitive or movement disorders
The purpose of this research is to improve diagnostic precision and expand the tools available for studying brain disorders.
Site Overview
Activity Indicator
Last 6 months
Trial Flow
How this site's trials are distributed across therapeutic areas and active substances (IMPs), and how they're positioned within their overall lifecycle status. Flow thickness represents the number of unique trials.
Top 5 of 7 therapeutic areas and 12 of 13 IMPs, ranked by number of trials.
Compounds & Molecules Timeline
The time span of clinical-trial activity for the main active substances (IMPs) studied at this site over the last 8 years. Each bar runs from the earliest trial start to the most recent end; a substance with a trial still open has no recorded end and is shown as ongoing.
Sponsor & Partnership
Top sponsors by active trials, and the ones that have come back for more than one study.
Sponsor Network
Top 4 by active trials.
- 1Karolinska Institutet2active
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Partnership History
Sponsors with repeated collaboration (≥ 2 trials).
- 1Karolinska Institutet3trials
Sponsor Network Graph
How sponsors and therapeutic areas connect across this site's active trials: each link is at least one active trial shared between them, and bigger nodes mean more activity. Click a node to see its exact connections.
Country Benchmark
Compared to 188 other sites in Sweden
Therapeutic Area Benchmark — Sweden
Select a therapeutic area to compare against other sites in Sweden.
Competitor Comparison
Similar sites in the same country running a comparable number of trials (within ±30%), scored on how closely their trial portfolios match this one. Higher percentages mean a more similar profile.
Country: Sweden
Market Share
Country: Sweden
Therapeutic Area Market Share
Select a therapeutic area to view its disease coverage breakdown.
Heat Maps & Advanced Analytics
How often specific conditions appear in trials across this site and comparable sites from the same country. Each row is a site, each column a condition, and each cell the number of trials on it — darker means more activity.
Other Trials in Karolinska Institutet
lock Showing 1 of 10 trials — the rest is available on a paid plan.
| Trial | Sponsor | Phase | Status | Start Date | End Date |
|---|---|---|---|---|---|
| Evaluation of [11C]Savolitinib Brain Penetration in Healthy Volunteers | AstraZeneca AB | Phase I | Not Recruiting | Mar 2024 | Jun 2024 |
IMP list
lock Showing 1 of 13 compounds — the rest is available on a paid plan.
| IMP | Trials | Status | First start | Last start |
|---|---|---|---|---|
| Acetylsalicylic Acid | 1 | Unknown | 2020-10-30 | 2020-10-30 |
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