Jeroen Bosch Ziekenhuis Stichting

At Jeroen Bosch Ziekenhuis Stichting, the Research Cardiology program focuses on cardiovascular diseases such as heart failure, myocardial infarction, atrial fibrillation, hypertension, and atherosclerotic disease. The trials are designed to test new treatments, improve early intervention, and better protect patients at high risk of major cardiac events.

• New approaches for acute myocardial infarction and post-heart attack recovery
• Treatments for heart failure, including patients with reduced or preserved ejection fraction
• Studies in atrial fibrillation and prevention of stroke-related complications
• Research on cardiovascular risk reduction in people with established disease or elevated lipoprotein(a)

Several studies at the site also examine whether treatment strategies can be made safer, more effective, or easier to use in everyday practice.

The site has a strong portfolio in oncology and hematologic malignancies, with research covering breast cancer, lung cancer, colorectal cancer, pancreatic cancer, prostate cancer, rectal cancer, and blood cancers such as acute myeloid leukemia, chronic lymphocytic leukemia, lymphoma, and multiple myeloma. These trials mainly aim to improve survival, refine treatment selection, and reduce treatment-related burden.

• Testing new cancer therapies and combination strategies for advanced solid tumors
• Improving outcomes after surgery or chemotherapy in rectal, pancreatic, and colorectal cancer
• Evaluating targeted and immune-based treatments in non-small cell lung cancer and other cancers
• Optimizing care for leukemia, lymphoma, and myeloma with an emphasis on effectiveness and tolerability

Much of this research is centered on finding treatments that are more precise, more durable, and better suited to each patient’s disease profile.

Clinical research here also includes neurological and immune-mediated diseases, especially multiple sclerosis and related inflammatory conditions. The studies are focused on comparing established therapies, personalizing treatment schedules, and maintaining disease control while limiting unnecessary exposure to medication.

• Research in multiple sclerosis, including relapsing and secondary progressive forms
• Comparisons of treatment strategies to keep MS activity under control
• Studies of personalized dosing and long-term effectiveness of ocrelizumab and related therapies
• Evaluation of alternative immune-targeted approaches for patients with prior treatment exposure

This work reflects a broader interest in making chronic neurological care more tailored and sustainable for patients.

The trial portfolio at Jeroen Bosch Ziekenhuis Stichting also spans digestive system diseases, nutritional and metabolic disorders, and kidney disease. Key conditions include Crohn’s disease, inflammatory bowel disease, obesity, type 2 diabetes, and chronic kidney disease. The main goal is to improve symptom control, long-term outcomes, and treatment convenience.

• New strategies for Crohn’s disease and other inflammatory bowel conditions
• Treatment studies in obesity and type 2 diabetes, including disease control in younger patients
• Research on chronic kidney disease and related cardiovascular complications
• Approaches to improve recovery and reduce complications in complex digestive surgery

These studies show a strong interest in managing chronic conditions that often overlap across multiple organ systems.

Another important area of research involves respiratory tract diseases, infectious diseases, and critical care. Trials address pneumonia, acute respiratory distress syndrome, sepsis, and broader hospital-based infection outcomes, with the aim of improving survival and recovery in seriously ill patients.

• Studies for acute respiratory distress syndrome and severe infection-related lung injury
• Research on sepsis and better treatment strategies in intensive care
• Trials in pneumonia and other acute respiratory infections
• Evaluation of interventions intended to improve hospital recovery and reduce complications

This area combines urgent care research with efforts to identify more effective supportive and disease-directed treatments.

The site also supports studies in female urogenital disease, male urogenital disease, and surgical procedures. Research includes prostate cancer, uterine fibroids, polycystic ovary syndrome, vulvar high-grade squamous intraepithelial lesion, and complex abdominal or pancreatic surgery. The overall purpose is to improve treatment effectiveness, recurrence prevention, and surgical outcomes.

• Trials in prostate cancer and other advanced urologic cancers
• Studies in uterine fibroids, PCOS, and vulvar HSIL
• Research on surgical infection prevention and recovery after major operations
• Evaluation of perioperative and adjuvant strategies in pancreatic and other abdominal cancers

Across these projects, the emphasis is on better recovery, fewer complications, and more durable disease control.