Hospital Universitario Hm Monteprincipe

At Hospital Universitario Hm Monteprincipe, clinical research in neoplasms focuses on children and young adults with advanced or relapsed cancers, including solid tumors, high-grade glioma, hepatoblastoma, hepatocellular carcinoma, and recurrent or relapsed solid tumours. These studies are designed to test new treatment combinations, improve tumor control, and better understand safety and tolerability in younger patients.

• Testing novel immunotherapy combinations for advanced pediatric and young adult cancers
• Evaluating treatment approaches for relapsed or difficult-to-treat brain and solid tumors
• Studying new options for liver cancers in children

Research in this area also includes work on somatostatin receptor-expressing tumors and broader efforts to improve outcomes while reducing treatment-related burden.

The site supports research in hemic and lymphatic diseases, with a strong focus on Langerhans Cell Histiocytosis. These trials aim to lower relapse rates, reduce late complications, and improve survival by refining treatment strategies for both high-risk and lower-risk forms of the disease.

• Improving disease control in multisystem and single-system Langerhans Cell Histiocytosis
• Reducing reactivations and long-term sequelae
• Exploring better treatment sequencing for patients who do not respond well to first-line therapy

This research reflects the department’s interest in rare pediatric conditions where careful treatment optimization can make a major difference in long-term health.

Clinical trials in cardiovascular diseases and nutritional and metabolic diseases at the site include studies in acute myocardial infarction, acute coronary syndrome, atherosclerotic cardiovascular disease, and chronic kidney disease. The main goal is to evaluate new ways to prevent major cardiovascular events and improve protection for people at high risk.

• Assessing therapies intended to reduce heart attack and stroke risk
• Studying prevention strategies for patients with established cardiovascular disease
• Exploring treatments that may improve outcomes in patients with kidney-related cardiovascular risk

These studies combine prevention and treatment research, aiming to support better long-term cardiovascular health.

In the area of bacterial infections and mycoses and virus diseases, the site is involved in trials addressing serious infections in infants, children, and adolescents. Key conditions include complicated urinary tract infection, blood stream infection, hospital-acquired pneumonia, ventilator-associated pneumonia, sepsis, and infections caused by gram-negative pathogens and Respiratory Syncytial Virus.

• Evaluating new antibiotic options for serious pediatric bacterial infections
• Studying prevention and treatment approaches for RSV in infants and children
• Assessing therapies for hospital-related and bloodstream infections

Work in this field also includes studies of COVID-19, SARS-CoV-2 infection, and vaccine responses in younger populations.

The research portfolio includes preventive studies in virus diseases and broader immunology, with trials focused on measles, mumps, rubella, varicella, RSV, and COVID-19. These trials aim to assess immune response, safety, and the potential value of vaccines and antibody-based prevention in children, adolescents, and adults.

• Measuring immune responses to combined childhood vaccines
• Evaluating protection against RSV in infants and children at increased risk
• Studying vaccine combinations and booster strategies for respiratory viruses

This area highlights the site’s role in helping improve infection prevention across different age groups.

Within hormonal diseases and nutritional and metabolic diseases, the site conducts pediatric studies on growth and metabolism, including short stature, Turner syndrome, Noonan syndrome, idiopathic short stature, lactose intolerance, and hypolactasia. The purpose of this research is to improve diagnosis and compare treatment options that support healthy growth and metabolic care.

• Comparing therapies for children who need help growing
• Improving diagnostic tools for lactose-related symptoms
• Supporting better identification of metabolic and endocrine conditions in pediatric care

These studies are especially relevant for children whose growth or digestive symptoms require careful long-term follow-up.

The site also contributes to studies in reproductive and urinary physiological phenomena, including research on prevention of pregnancy and treatment of urinary infections. In parallel, it participates in trials related to cancer-associated thrombosis, reflecting an interest in both reproductive health and clot prevention in patients with cancer.

• Evaluating contraceptive effectiveness and tolerability
• Studying better care for urinary tract and kidney infections
• Assessing ways to reduce clotting risk in people receiving cancer treatment

These trials add breadth to the site’s research portfolio by addressing everyday clinical needs alongside more specialized disease areas.