Hospital Universitario De La Princesa

At Hospital Universitario De La Princesa, a large share of research focuses on cancer and blood disorders, including breast cancer, lung cancer, prostate cancer, bladder cancer, multiple myeloma, leukemia, and lymphoma. These studies are mainly designed to test new treatment options, compare them with current standard care, and improve disease control and survival.

• New approaches for solid tumors such as non-small cell lung cancer, urothelial carcinoma, and breast cancer
• Treatment strategies for multiple myeloma, CLL/SLL, AML, and other hematologic cancers
• Trials aimed at improving response rates, delaying progression, and refining modern oncology care

The site’s Clinical pharmacology department supports a broad portfolio of studies that explore both targeted therapies and combination treatments in advanced and newly diagnosed disease.

A strong research theme at the site is cardiovascular disease, with trials in acute myocardial infarction, stroke, coronary artery disease, heart valve disease, hypertension, hypercholesterolemia, and diabetes. These studies typically aim to reduce major cardiac events, improve prevention, and evaluate better treatment options for high-risk patients.

• Prevention and treatment studies in atherosclerotic cardiovascular disease and high-risk vascular disease
• Research on myocardial infarction, stroke prevention, and transcatheter aortic valve implantation
• Trials addressing lipid lowering, inflammation, and overall cardiovascular risk reduction

This portfolio reflects a broad effort to improve outcomes for patients with both established disease and those at elevated risk.

The site also conducts extensive research in neurology, especially Parkinson’s disease, multiple sclerosis, epilepsy, and other disorders affecting movement and cognition. The main purpose of these trials is to assess symptom relief, slow progression, and support long-term disease management.

• Studies in Parkinson’s disease, including tremor, motor fluctuations, and autonomic symptoms
• Research in multiple sclerosis focused on relapse control and long-term safety
• Trials in focal seizures, cognitive impairment, and related neurodegenerative conditions

These investigations aim to improve daily function and quality of life for people living with chronic neurological illness.

Another major area of research includes digestive system diseases and liver disease, with trials in Crohn’s disease, ulcerative colitis, eosinophilic esophagitis, acute pancreatitis, alcohol-related liver disease, and drug-induced liver injury. The goal is to improve symptom control, healing, and safety of treatment in complex inflammatory and liver conditions.

• Studies testing new therapies for inflammatory bowel disease and related complications
• Research on esophageal inflammation and rare digestive disorders
• Trials evaluating better management of liver injury and acute pancreatitis

The research activity in this area highlights the site’s interest in chronic inflammation and organ-specific disease control.

Respiratory diseases and allergic disorders are another important focus, including asthma, COPD, idiopathic pulmonary fibrosis, progressive fibrosing interstitial lung disease, allergic rhinitis, and urticaria. These trials are generally designed to improve symptom control, reduce flare-ups, and test more effective long-term treatments.

• Research in severe asthma, COPD, and chronic cough
• Studies in pulmonary fibrosis and other interstitial lung diseases
• Trials for allergic rhinoconjunctivitis, prurigo nodularis, and chronic urticaria

This area combines chronic respiratory care with immune-mediated skin and allergy research, supporting a broad approach to symptom relief and disease control.

The site has active studies in immune system diseases, rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, psoriasis, hidradenitis suppurativa, and atopic dermatitis. These trials aim to reduce inflammation, improve skin and joint symptoms, and evaluate whether newer therapies offer better disease control.

• Trials in autoimmune disease and inflammatory arthritis
• Studies in psoriasis, eczema, and other chronic skin conditions
• Research focused on improving control of immune-mediated inflammation

This work reflects a strong interest in conditions where the immune system plays a central role in ongoing tissue damage and symptoms.

The clinical trial portfolio also includes infectious diseases, kidney disease, and other specialized areas such as urogenital disorders, pain, and mental health. Research topics include HIV, hepatitis B, candidemia, urinary tract infections, chronic kidney disease, and acute kidney injury, with studies often focused on prevention, safety, and better treatment effectiveness.

• Trials in viral, bacterial, and fungal infections
• Studies targeting renal disease and kidney protection in high-risk patients
• Research in pain management, migraine, and selected psychiatric or cognitive conditions

Across these diverse programs, the site supports both common and uncommon conditions, with a consistent focus on improving patient outcomes through carefully evaluated therapies.