Fondazione IRCCS Policlinico San Matteo

At Fondazione IRCCS Policlinico San Matteo in Pavia, clinical trials in cardiovascular diseases and nutritional and metabolic disorders focus on major conditions such as atrial fibrillation, acute myocardial infarction, heart failure, atherosclerotic cardiovascular disease, and hypertriglyceridemia. These studies are designed to test new treatments, reduce serious cardiovascular events, and improve long-term disease control.

• New approaches for preventing stroke and other embolic events in atrial fibrillation
• Treatments aimed at lowering the risk of heart attack and recurrent cardiovascular events
• Studies targeting heart failure, myocarditis, and transthyretin-mediated amyloid cardiomyopathy
• Research on controlling high triglycerides and broader metabolic risk

This area also includes work on improving outcomes in patients with established cardiovascular disease through safer and more effective therapies.

A large share of the research portfolio centers on neoplasms and hemic and lymphatic diseases, with studies in lung cancer, renal cell carcinoma, breast cancer, melanoma, esophageal carcinoma, and blood cancers such as acute myeloid leukemia, acute lymphoblastic leukemia, lymphoma, multiple myeloma, and myelodysplastic syndromes. The goal is to evaluate new cancer therapies, improve survival, and refine treatment strategies across solid tumors and hematologic malignancies.

• Testing new treatment combinations for advanced non-small cell lung cancer and renal cancer
• Studies in lymphoma, multiple myeloma, and myelodysplastic syndromes to improve disease control
• Research in melanoma and breast cancer aimed at extending progression-free survival
• Pediatric and adult trials in acute leukemia focused on better outcomes and response rates

The site’s oncology program reflects broad expertise in both solid tumors and blood cancers, supporting studies that compare new options with current standard care.

Research in respiratory tract diseases, immune system diseases, and congenital, hereditary, and neonatal diseases includes trials for asthma, chronic obstructive pulmonary disease, bronchiectasis, pulmonary arterial hypertension, idiopathic pulmonary fibrosis, and lung transplant rejection. These studies aim to improve breathing symptoms, reduce flare-ups, and support transplant and chronic lung disease care.

• Evaluating new options for severe asthma in children, adolescents, and adults
• Trials in COPD and bronchiectasis to reduce exacerbations and improve daily function
• Studies for pulmonary arterial hypertension and pulmonary fibrosis to slow disease progression
• Research on chronic lung allograft dysfunction and lung transplant rejection

This respiratory portfolio combines symptom relief, disease modification, and long-term lung function preservation.

The site also conducts trials in immune system diseases, skin and connective tissue diseases, digestive system diseases, and virus diseases. Key areas include ulcerative colitis, polymyalgia rheumatica, systemic sclerosis-associated interstitial lung disease, chronic spontaneous urticaria, HIV-1 infection, and mpox virus disease. These studies are aimed at improving symptom control, reducing inflammation, and assessing treatment safety and effectiveness.

• New therapies for ulcerative colitis and other inflammatory bowel conditions
• Studies in polymyalgia rheumatica, systemic sclerosis, and related lung involvement
• Research on chronic spontaneous urticaria to better control persistent itching and hives
• Trials in HIV-1 and mpox focused on treatment effectiveness and safety

Together, these studies show a strong emphasis on immune-mediated conditions and selected infectious diseases, with a focus on practical improvements in patient care.

Additional research at Fondazione IRCCS Policlinico San Matteo includes eye diseases, musculoskeletal diseases, and related inflammatory conditions such as open-angle glaucoma, ocular hypertension, skin and connective tissue disorders, and polymyalgia rheumatica. The aim is to improve disease monitoring, preserve function, and evaluate therapies that may offer better control than current options.

• Studies to reduce pressure-related damage in glaucoma and ocular hypertension
• Research in polymyalgia rheumatica to achieve sustained remission
• Trials addressing inflammatory conditions that affect mobility and quality of life
• Work on better treatment options for chronic eye disease management

This part of the portfolio adds breadth to the site’s research profile, extending beyond major internal medicine and cancer programs.