Diakonessenhuis Stichting

The Diakonessenhuis Stichting Emergency Department is involved in studies across cardiovascular diseases, nutritional and metabolic disorders, and health care, with a strong focus on heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, hypertension, and type 2 diabetes. These trials are designed to test new treatment strategies and compare them with current standard care to improve long-term outcomes.

• Testing therapies aimed at reducing major cardiovascular events and heart-related hospitalizations
• Evaluating treatments for heart failure with reduced or preserved ejection fraction
• Studying weight-related approaches in obesity and type 2 diabetes care
• Assessing rhythm control and stroke prevention in atrial fibrillation

Several projects also explore whether earlier or simplified treatment approaches can maintain effectiveness while improving tolerability and patient convenience.

Research at this site includes multiple neoplasms, especially breast cancer, colorectal cancer, rectal cancer, pancreatic cancer, melanoma, and multiple myeloma. A key theme is finding better ways to treat cancer while preserving organ function and maintaining quality of life.

• Comparing treatment strategies for metastatic colorectal cancer and metastatic breast cancer
• Evaluating HER2-positive breast cancer and triple negative breast cancer treatments
• Studying organ-preserving approaches in early rectal cancer
• Assessing new options for metastatic pancreatic cancer and advanced NSCLC

These trials aim to improve cancer control, reduce treatment burden, and support better recovery after therapy.

Clinical trials at Diakonessenhuis Stichting also cover respiratory tract diseases, virus diseases, and kidney disease, reflecting the broad scope of emergency and acute care research. Current studies include respiratory tract infection, RSV, and advanced chronic kidney disease, with an emphasis on improving outcomes in hospitalized and high-risk patients.

• Testing interventions for hospitalized patients with acute respiratory tract infection
• Studying prevention of RSV in infants and pregnancy-related immunization strategies
• Evaluating therapies to slow progression in chronic kidney disease
• Looking at combined kidney and cardiovascular protection in people with advanced renal disease

This area of research focuses on better prevention, earlier treatment, and improved recovery in acute and chronic conditions.

The site is also active in nervous system diseases, mental disorders, and reproductive and urinary physiological phenomena. Studies include multiple sclerosis, posttraumatic stress disorder, obesity-related reproductive conditions, and contraception research, showing a broad interest in both long-term disease management and preventive care.

• Assessing personalized treatment approaches in multiple sclerosis
• Testing approaches for symptom relief after trauma in PTSD
• Studying fertility-related care in polycystic ovary syndrome
• Evaluating new options for contraception and women’s health

These trials are aimed at improving daily functioning, patient choice, and the overall quality of care in conditions that often require long-term follow-up.

Research in bacterial infections and mycoses, virus diseases, and analytical and diagnostic techniques includes studies on group B streptococcus, vulvar high-grade squamous intraepithelial lesion, and other infection-related conditions. The work also reflects interest in improving prevention, diagnosis, and risk assessment in maternal and infectious disease care.

• Testing vaccines and preventive strategies for group B streptococcus in pregnancy and newborns
• Evaluating vaccination to reduce recurrence in vulvar HSIL
• Studying new ways to detect or predict treatment response in selected cancers
• Exploring public health and care organization topics linked to emergency medicine

These studies support safer care for mothers and infants while also advancing tools for prevention and clinical decision-making.