Charles University Hospital
- Address
- V Uvalu 84/1 Motol, 150 00 Prague, Czechia
Charles University Hospital - Pediatric Oncology and Hepatic Tumors
Charles University Hospital is a leading center for pediatric hepatic tumor research, participating in the international PHITT (Paediatric Hepatic International Tumour Trial) study. The center specializes in risk-stratified treatment approaches for rare childhood liver cancers, focusing on optimizing chemotherapy protocols while minimizing toxicity in pediatric patients.
- Hepatoblastoma treatment across risk categories from very low-risk to high-risk disease
- Hepatocellular carcinoma management in pediatric populations
- Novel combination chemotherapy regimens including targeted therapies with sorafenib
- Biological sample collection and toxicity studies for treatment optimization
The hospital's research program evaluates multiple therapeutic strategies, including dose-compressed chemotherapy protocols and comparative studies of regimens such as cisplatin, carboplatin, doxorubicin, gemcitabine, and oxaliplatin combinations. Special emphasis is placed on metastatic disease clearance and treatment de-escalation studies for patients achieving early remission, contributing to international efforts to establish evidence-based standards for these rare pediatric malignancies.
Site Overview
Activity Indicator
Last 6 months
Trial Flow
How this site's trials are distributed across therapeutic areas and active substances (IMPs), and how they're positioned within their overall lifecycle status. Flow thickness represents the number of unique trials.
Compounds & Molecules Timeline
The time span of clinical-trial activity for the main active substances (IMPs) studied at this site over the last 8 years. Each bar runs from the earliest trial start to the most recent end; a substance with a trial still open has no recorded end and is shown as ongoing.
Sponsor & Partnership
Top sponsors by active trials, and the ones that have come back for more than one study.
Sponsor Network
Top 2 by active trials.
- 1Nsc Therapeutics GmbH1active
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Partnership History
Sponsors with repeated collaboration (≥ 2 trials).
No repeated partnerships found.
Sponsor Network Graph
How sponsors and therapeutic areas connect across this site's active trials: each link is at least one active trial shared between them, and bigger nodes mean more activity. Click a node to see its exact connections.
Country Benchmark
Compared to 634 other sites in Czechia
Therapeutic Area Benchmark — Czechia
Select a therapeutic area to compare against other sites in Czechia.
Competitor Comparison
Similar sites in the same country running a comparable number of trials (within ±30%), scored on how closely their trial portfolios match this one. Higher percentages mean a more similar profile.
Country: Czechia
Market Share
Country: Czechia
Therapeutic Area Market Share
Select a therapeutic area to view its disease coverage breakdown.
Heat Maps & Advanced Analytics
How often specific conditions appear in trials across this site and comparable sites from the same country. Each row is a site, each column a condition, and each cell the number of trials on it — darker means more activity.
Other Trials in Charles University Hospital
lock Showing 1 of 2 trials — the rest is available on a paid plan.
| Trial | Sponsor | Phase | Status | Start Date | End Date |
|---|---|---|---|---|---|
| Evaluation of Cisplatin-Based Regimens and Drug Combinations in Pediatric Hepatoblastoma and Hepatocellular Carcinoma: A Multicenter Clinical Trial | The University Of Birmingham | Phase III | Recruiting | Mar 2018 | — |
IMP list
lock Showing 1 of 12 compounds — the rest is available on a paid plan.
| IMP | Trials | Status | First start | Last start |
|---|---|---|---|---|
| (S)-2-ETHYL-8-METHYL-1-THIA-4,8-DIAZASPIRO[4.5]DECAN-3-ONE | 1 | Unknown | 2025-08-25 | 2025-08-25 |
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