Casa Di Cura Macchiarella S.p.A.
- Address
- Viale Regina Margherita 25, 90138 Palermo, Italy
Casa Di Cura Macchiarella S.p.A. - Oncology Research Center
Casa Di Cura Macchiarella S.p.A. is a specialized oncology research facility dedicated to advancing multimodal cancer treatment approaches. The center demonstrates expertise in combining novel pharmacological interventions with established radiation and chemotherapy protocols, focusing on optimizing treatment outcomes for gastrointestinal and urological malignancies.
- Locally advanced rectal cancer with neoadjuvant combination therapies
- Intermediate risk prostate cancer with ultra-hypofractionated radiotherapy
- Integration of metabolic agents (aspirin and metformin) in oncologic treatment protocols
The center's research portfolio includes innovative approaches such as ultra-hypofractionated radiotherapy combined with hormonal agents for prostate cancer, and the evaluation of aspirin and metformin as adjunctive therapies during neoadjuvant induction chemotherapy and chemoradiotherapy for rectal cancer. These trials demonstrate a commitment to exploring how repurposed medications and optimized radiation schedules can improve pathological response rates and biochemical outcomes in solid tumor management.
Site Overview
Activity Indicator
Last 6 months
Trial Flow
How this site's trials are distributed across therapeutic areas and active substances (IMPs), and how they're positioned within their overall lifecycle status. Flow thickness represents the number of unique trials.
Top 3 therapeutic areas and 15 of 19 IMPs, ranked by number of trials.
Compounds & Molecules Timeline
The time span of clinical-trial activity for the main active substances (IMPs) studied at this site over the last 8 years. Each bar runs from the earliest trial start to the most recent end; a substance with a trial still open has no recorded end and is shown as ongoing.
Sponsor & Partnership
Top sponsors by active trials, and the ones that have come back for more than one study.
Sponsor Network
Top 5 by active trials.
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Partnership History
Sponsors with repeated collaboration (≥ 2 trials).
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Sponsor Network Graph
How sponsors and therapeutic areas connect across this site's active trials: each link is at least one active trial shared between them, and bigger nodes mean more activity. Click a node to see its exact connections.
Country Benchmark
Compared to 566 other sites in Italy
Therapeutic Area Benchmark — Italy
Select a therapeutic area to compare against other sites in Italy.
Competitor Comparison
Similar sites in the same country running a comparable number of trials (within ±30%), scored on how closely their trial portfolios match this one. Higher percentages mean a more similar profile.
Country: Italy
Market Share
Country: Italy
Therapeutic Area Market Share
Select a therapeutic area to view its disease coverage breakdown.
Heat Maps & Advanced Analytics
How often specific conditions appear in trials across this site and comparable sites from the same country. Each row is a site, each column a condition, and each cell the number of trials on it — darker means more activity.
Other Trials in Casa Di Cura Macchiarella S.p.A.
lock Showing 1 of 8 trials — the rest is available on a paid plan.
| Trial | Sponsor | Phase | Status | Start Date | End Date |
|---|---|---|---|---|---|
| A phase II, open label, multicenter trial investigating Irinotecan plus cetuximab rechallenge compared with trifluridine/tipiracil plus bevacizumab as third line treatment in circulating tumor DNA molecularly selected metastatic colorectal cancer: the ROMANCE-GOIM trial | Gruppo Oncologico Dell'Italia Meridionale | Phase II | Recruiting | Mar 2026 | — |
IMP list
lock Showing 1 of 19 compounds — the rest is available on a paid plan.
| IMP | Trials | Status | First start | Last start |
|---|---|---|---|---|
| Bevacizumab | 4 | Unknown | 2019-01-03 | 2026-03-11 |
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