Azienda Provinciale Per I Servizi Sanitari

At Azienda Provinciale Per I Servizi Sanitari, clinical trials in oncology focus strongly on breast cancer, including early-stage, hormone receptor-positive, triple-negative, HER2-positive, and metastatic disease. These studies are designed to test new treatment approaches, compare active therapies, and improve outcomes after surgery or standard treatment.

• Testing new combinations for triple-negative breast cancer and high-risk disease after surgery
• Evaluating targeted and endocrine-based strategies in hormone receptor-positive, HER2-negative breast cancer
• Studying treatment options for metastatic breast cancer and HER2-positive breast cancer

Research in this area aims to extend disease control, reduce recurrence, and better tailor treatment to the biology of each tumor.

The site has a major research focus on prostate cancer, especially metastatic castration-resistant and metastatic castration-sensitive prostate cancer. Trials are exploring new hormonal, targeted, and combination therapies to improve survival, delay progression, and support men with advanced disease.

• Investigating treatment effectiveness in mCRPC and mCSPC
• Studying therapies for patients with HRR or BRCA-related tumor features
• Assessing symptom control and quality of life in advanced prostate cancer

These studies reflect a broad effort to refine care for advanced genitourinary cancers and identify more personalized treatment pathways.

Clinical research at the U.O. di Oncologia Medica Ospedale S. Chiara -Trento also includes melanoma, with trials centered on immunotherapy and newer treatment combinations. The goal is to improve disease control in advanced and metastatic cases while comparing promising options against current standard care.

• Evaluating immune-based treatment strategies for advanced melanoma
• Comparing new combinations with established checkpoint inhibitor approaches
• Measuring progression control and overall benefit in metastatic skin cancer

This area highlights the site’s role in advancing treatments that harness the immune system against aggressive cancers.

Another important field is colorectal cancer, where trials are examining how to improve treatment after surgery and in advanced disease. Several studies focus on ctDNA-guided strategies, aiming to better identify patients who may benefit from treatment intensification or closer follow-up.

• Testing treatment strategies for stage III and high-risk resected colon cancer
• Exploring sequencing approaches in metastatic colorectal cancer
• Using ctDNA to support more precise post-operative decision-making

These studies are designed to improve recurrence prevention and make treatment planning more individualized for patients with gastrointestinal cancers.

Trials in gynecologic oncology include research on endometrial cancer, particularly recurrent or advanced disease. The studies are aimed at evaluating whether new treatment combinations can improve survival and delay disease progression.

• Studying treatment options for advanced endometrial cancer
• Assessing benefit in different tumor subgroups, including MMR and MSI profiles
• Comparing combination approaches with standard therapy

This work supports better treatment selection for women with difficult-to-treat female reproductive system cancers.

Beyond cancer, the site participates in studies on immune system diseases, kidney cancer, and lung cancer. These trials are focused on testing new therapies, improving disease control, and evaluating whether surgery or other treatment strategies add benefit alongside modern systemic care.

• Investigating treatment for eosinophilic granulomatosis with polyangiitis
• Studying approaches for metastatic renal cell carcinoma and metastatic NSCLC
• Evaluating whether treatment strategies can improve survival and disease management

This broad portfolio shows active research across both oncology and selected inflammatory diseases, with an emphasis on better outcomes and more effective care.

The site also contributes to trials in diagnostic techniques, supportive care, and procedure-related research. These studies aim to improve how patients are prepared, monitored, and treated in routine clinical settings, including research relevant to colonoscopy and pain management.

• Improving bowel preparation for colonoscopy
• Testing a new approach for chronic pelvic pain syndrome
• Supporting better diagnostic and treatment-related clinical practice

Such studies complement the oncology program by addressing patient comfort, diagnostic quality, and everyday care needs at the hospital level.