Azienda Ospedaliero Universitaria Di Modena

At Azienda Ospedaliero Universitaria Di Modena, research in Respiratory Tract Diseases and Virus Diseases focuses on conditions such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, asthma, bronchiectasis, and post-acute COVID syndrome. These studies are designed to better understand disease progression and evaluate new treatment strategies for people with complex lung and infectious diseases.

• Chronic lung disease, including COPD, bronchiectasis, and progressive pulmonary fibrosis
• Severe respiratory conditions such as idiopathic pulmonary fibrosis and acute respiratory distress syndrome
• Infectious disease research covering HIV, hepatitis B, fungal infections, and recurrent Clostridioides difficile infection
• Trials aiming to improve symptom control, reduce complications, and assess treatment effectiveness

The site also contributes to studies in immune system diseases linked to respiratory inflammation and infection-related complications.

A major part of the trial portfolio at this hospital in Modena is devoted to Neoplasms, with a strong emphasis on breast cancer, lung cancer, gastrointestinal cancers, ovarian cancer, and pancreatic cancer. The research is centered on testing new therapies, improving outcomes after standard treatment, and finding better ways to delay recurrence or spread.

• Breast cancer, including HER2-positive, HER2-negative, triple-negative, and hormone receptor-positive disease
• Lung cancer studies spanning non-small cell and small cell disease
• Gastric, colorectal, pancreatic, and head and neck cancers
• Studies evaluating new combinations, maintenance approaches, and post-surgery treatment strategies

Many of these trials explore whether emerging cancer therapies can improve survival or extend the time before disease progression.

The research program includes extensive work in Hemic and Lymphatic Diseases, especially acute leukemias, chronic lymphocytic leukemia, lymphomas, multiple myeloma, and inherited or acquired blood disorders. These studies are aimed at refining treatment choices, supporting deeper disease control, and improving long-term outcomes for patients with difficult-to-treat hematologic conditions.

• Acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myeloid leukemia
• Chronic lymphocytic leukemia, diffuse large B-cell lymphoma, mantle cell lymphoma, and marginal zone lymphoma
• Multiple myeloma and other plasma cell disorders
• Blood-related conditions such as sickle cell disease, thalassemia, and thrombocytopenia

This area includes trials testing new drug combinations and strategies to reduce relapse risk and improve disease response.

Research in Immune System Diseases, Skin and Connective Tissue Diseases, and kidney disorders addresses illnesses such as systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, IgA nephropathy, and lupus nephritis. The goal is to evaluate treatments that can better control inflammation, protect organ function, and reduce long-term complications.

• Autoimmune diseases affecting the kidneys, joints, skin, and internal organs
• Inflammatory bowel disease, including ulcerative colitis
• Renal conditions such as IgA nephropathy, chronic kidney disease, and end-stage kidney disease
• Trials focused on symptom relief, disease control, and preservation of kidney function

The site also studies hidradenitis suppurativa, psoriasis, and other chronic inflammatory skin conditions.

A notable part of the portfolio covers Nervous System Diseases and neurodegenerative disorders, including multiple sclerosis, Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and epilepsy. These trials are intended to test new therapies, improve symptom management, and slow disease progression in conditions that can strongly affect daily life.

• Multiple sclerosis and relapsing inflammatory neurological disease
• Alzheimer’s disease, frontotemporal dementia, and related cognitive disorders
• Amyotrophic lateral sclerosis and other progressive neurodegenerative illnesses
• Headache, migraine, and refractory epilepsy research

Research in this area often aims to preserve function, reduce relapses, and improve quality of life over time.

The site also conducts studies in Cardiovascular Diseases, Nutritional and Metabolic Diseases, and Digestive System Diseases. Key topics include atherosclerotic cardiovascular disease, hypertension, atrial fibrillation, metabolic dysfunction-associated steatohepatitis, and primary biliary cholangitis. These trials are focused on prevention, risk reduction, and better long-term disease management.

• Heart and vascular disease, including elevated cardiovascular risk and atrial fibrillation
• Liver and biliary disorders such as MASH/NASH, primary biliary cholangitis, and chronic hepatitis B
• Metabolic conditions including severe hypertriglyceridemia and obesity-related disease
• Studies evaluating whether new treatments can reduce complications and improve clinical outcomes

This research reflects a broad interest in preventing major organ damage and improving chronic disease control.

Beyond the major disease groups, Azienda Ospedaliero Universitaria Di Modena participates in trials for rare diseases, congenital disorders, and selected pediatric conditions. Examples include Langerhans cell histiocytosis, Prader-Willi syndrome, generalized epidermolysis bullosa simplex, and congenital adrenal hyperplasia. These studies aim to improve diagnosis, refine treatment options, and address unmet needs in less common diseases.

• Rare inherited and developmental disorders
• Pediatric hematology and oncology, including leukemia and neuroblastoma
• Specialized reproductive and pregnancy-related research
• Trials designed to generate better care options where standard treatments are limited

The breadth of this work shows a strong commitment to both common and uncommon conditions across the clinical spectrum.