Azienda Ospedaliera Universitaria San Giovanni Di Dio E Ruggi d'Aragona

At Azienda Ospedaliera Universitaria San Giovanni Di Dio E Ruggi d'Aragona, the U.O.C. Neurologia is involved in research on nervous system diseases and related mental disorders, with a strong focus on conditions that affect memory, movement, and behavior.

• Alzheimer’s disease and psychosis associated with Alzheimer’s disease, including studies aimed at improving symptom control and long-term care
• Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy, with trials designed to slow disease progression and evaluate new therapies
• Lewy body dementia psychosis, exploring better options for managing neuropsychiatric symptoms
• Progressive forms of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy, focused on treatment effectiveness and safety

These studies mainly test new treatments and assess whether emerging therapies can better preserve function, reduce symptoms, and improve quality of life in patients with complex neurological conditions.

The site has extensive activity in hemic and lymphatic diseases and neoplasms, reflecting a broad program in blood cancers and related disorders.

• Acute myeloid leukemia, acute lymphoblastic leukemia, and Philadelphia chromosome-positive ALL, with research aimed at improving remission rates and disease control
• Chronic lymphocytic leukemia, multiple myeloma, follicular lymphoma, and diffuse large B-cell lymphoma, evaluating more effective treatment strategies
• Myelodysplastic syndromes and anemia linked to marrow disorders, with trials focused on transfusion needs and clinical benefit
• Haematopoietic stem cell transplant-associated thrombotic microangiopathy, where studies aim to improve outcomes after transplant

Research in this area is centered on testing new combinations, refining treatment choices, and measuring how well therapies clear residual disease in patients with difficult-to-treat blood cancers.

Clinical trials at this hospital in Salerno also cover a wide range of immune system diseases and inflammatory conditions, with attention to both chronic symptoms and disease activity.

• Sjögren’s syndrome and systemic lupus erythematosus, studying therapies that may reduce inflammation and improve disease control
• Rheumatoid arthritis, exploring better long-term management approaches
• Hereditary angioedema and chronic spontaneous urticaria, focused on preventing attacks and reducing symptom burden
• Systemic mastocytosis, including indolent and advanced forms, with research aimed at easing symptoms and improving safety of treatment

These studies are designed to evaluate new immune-targeted therapies, confirm safety, and help patients achieve more stable disease control over time.

The research portfolio includes several respiratory tract diseases, digestive system diseases, and skin and connective tissue diseases, showing a broad interest in inflammatory and allergic conditions.

• Asthma, including severe asthma and eosinophilic asthma, with trials aimed at reducing exacerbations and medication burden
• Chronic obstructive pulmonary disease, studying ways to lower flare-up risk and improve symptom control
• Eosinophilic esophagitis, focusing on reducing inflammation and swallowing problems
• Chronic spontaneous urticaria and other inflammatory skin-related conditions, evaluating relief of persistent symptoms

Across these areas, the site is testing new biologic and targeted approaches to improve everyday disease management and reduce the impact of long-term inflammation.

Research also extends into cardiovascular diseases, congenital and hereditary conditions, and other complex disorders, including studies of both prevention and treatment effectiveness.

• Atherosclerotic cardiovascular disease and broader cardiovascular disease, with trials focused on lowering risk of major heart and vascular events
• Low-cardiac output syndrome, evaluating support strategies around cardiac surgery
• Haemophilia A, studying long-term prevention of bleeding episodes
• Von-Hippel Lindau disease and decompensated cirrhosis, where research explores diagnostic, theranostic, and supportive treatment options

These trials aim to improve detection, prevention, and symptom management in conditions where careful long-term care can make a major difference for patients.