Azienda Ospedaliera Universitaria Federico II Di Napoli

At Azienda Ospedaliera Universitaria Federico II Di Napoli, a strong focus on cardiology supports studies in cardiovascular diseases, including atherosclerotic cardiovascular disease, acute coronary syndrome, atrial fibrillation, and myocardial infarction. These trials are designed to test new ways to prevent major heart and vascular events and improve long-term outcomes.

• Preventing major cardiovascular events in people at high risk
• Evaluating treatments for atrial fibrillation and stroke prevention
• Studying therapies aimed at reducing recurrent heart attacks and coronary complications

This research also includes approaches for patients with elevated lipoprotein(a) and other risk factors, reflecting a broad effort to improve both prevention and treatment in cardiovascular care.

The site is active in hemic and lymphatic diseases, with trials focused on diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, and multiple myeloma. The main goal is to compare new treatment combinations with current standards and improve disease control for patients with blood cancers.

• Testing new immunotherapy-based approaches for lymphoma
• Comparing combination treatments with established chemotherapy or antibody regimens
• Evaluating strategies to extend remission and reduce relapse risk

Several studies at Azienda Ospedaliera Universitaria Federico II Di Napoli are also exploring whether these treatments can offer better effectiveness with acceptable safety in both newly diagnosed and relapsed disease.

Research in nutritional and metabolic diseases and hormonal diseases includes type 2 diabetes, obesity, overweight, nonalcoholic steatohepatitis, and congenital adrenal hyperplasia. These trials aim to improve blood sugar control, support weight management, and address hormone-related conditions with more effective treatment options.

• Studying new therapies for better glucose control in type 2 diabetes
• Assessing treatments for obesity-related and liver-related metabolic disease
• Exploring hormone-targeted approaches in congenital adrenal hyperplasia

The overall focus is on finding treatments that may help patients manage chronic metabolic conditions more safely and effectively over time.

Trials in immune system diseases and related organ disorders include primary IgA nephropathy, idiopathic immune complex mediated membranoproliferative glomerulonephritis, chronic kidney disease, and kidney complications linked to surgery or cardiovascular illness. The research is centered on reducing inflammation, lowering proteinuria, and protecting kidney function.

• Testing therapies for proteinuria and progression in kidney disease
• Evaluating protection against kidney injury in high-risk patients
• Studying immune-driven kidney disorders with limited treatment options

These studies reflect a combined interest in nephrology and immunology, with the aim of improving outcomes in complex chronic disease.

The oncology portfolio covers neoplasms such as breast cancer, metastatic non-small cell lung cancer, melanoma, and advanced malignancies. Research is directed at testing new cancer therapies, improving recurrence prevention, and comparing emerging treatments with current standards of care.

• Studying treatments for early and advanced breast cancer
• Evaluating new options for lung cancer and melanoma
• Investigating strategies to reduce relapse after initial cancer treatment

This activity shows a broad commitment to oncology, with ongoing work aimed at improving both survival and disease control across several cancer types.

The site also studies immune system diseases affecting the skin, including atopic dermatitis, hidradenitis suppurativa, cutaneous lupus erythematosus, and alopecia areata. These trials are designed to assess whether new therapies can better control symptoms and improve quality of life in chronic inflammatory skin conditions.

• Testing treatments for moderate to severe eczema and related skin inflammation
• Evaluating therapies for autoimmune hair loss and lupus-related skin disease
• Studying options for chronic painful skin disorders such as hidradenitis suppurativa

The research combines dermatology and immunology, reflecting a strong interest in conditions where immune activity drives persistent skin symptoms.

Additional trials at the Naples site involve nervous system diseases, eye diseases, and selected rare disorders such as Tourette’s disorder, Friedreich’s ataxia, glaucoma, and thyroid eye disease. The purpose of this research is to evaluate symptom control, preserve function, and improve care for conditions that often have limited treatment choices.

• Studying therapies for movement and neurodevelopmental disorders
• Assessing treatments to protect vision in glaucoma and thyroid eye disease
• Exploring options for rare inherited and neurological conditions

These studies broaden the research profile of Azienda Ospedaliera Universitaria Federico II Di Napoli, showing activity across both common chronic diseases and less frequent specialized conditions.