Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello
- Address
- Via Trabucco 180, 90146 Palermo, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Hematologic Malignancies Research
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello is actively engaged in advancing precision medicine approaches for hematologic malignancies, with particular expertise in acute myeloid leukemia (AML) research. The center focuses on innovative biomarker-driven treatment strategies designed to optimize therapeutic outcomes for patients with specific genetic mutations.
- FLT3-mutated acute myeloid leukemia therapeutic optimization
- Biomarker-guided personalized treatment protocols using peripheral blast clearance (PBC)
- Intensified chemotherapy regimens and allogeneic transplantation strategies
The research center emphasizes chemosensitivity prediction through the measurement of peripheral blast clearance to identify patients who may benefit from early treatment intensification. Their approach combines high-dose induction therapy with strategic consolidation phase planning, including allocation to allogeneic stem cell transplantation, aimed at improving event-free survival rates in genetically defined patient populations.
Site Overview
Activity Indicator
Last 6 months
Trial Flow
How this site's trials are distributed across therapeutic areas and active substances (IMPs), and how they're positioned within their overall lifecycle status. Flow thickness represents the number of unique trials.
Top 5 of 10 therapeutic areas and 15 of 178 IMPs, ranked by number of trials.
Compounds & Molecules Timeline
The time span of clinical-trial activity for the main active substances (IMPs) studied at this site over the last 8 years. Each bar runs from the earliest trial start to the most recent end; a substance with a trial still open has no recorded end and is shown as ongoing.
Top 40 of 176 compounds, ranked by number of trials.
Sponsor & Partnership
Top sponsors by active trials, and the ones that have come back for more than one study.
Sponsor Network
Top 27 by active trials.
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Partnership History
Sponsors with repeated collaboration (≥ 2 trials).
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Sponsor Network Graph
How sponsors and therapeutic areas connect across this site's active trials: each link is at least one active trial shared between them, and bigger nodes mean more activity. Click a node to see its exact connections.
Country Benchmark
Compared to 566 other sites in Italy
Therapeutic Area Benchmark — Italy
Select a therapeutic area to compare against other sites in Italy.
Competitor Comparison
Similar sites in the same country running a comparable number of trials (within ±30%), scored on how closely their trial portfolios match this one. Higher percentages mean a more similar profile.
Country: Italy
Market Share
Country: Italy
Therapeutic Area Market Share
Select a therapeutic area to view its disease coverage breakdown.
Heat Maps & Advanced Analytics
How often specific conditions appear in trials across this site and comparable sites from the same country. Each row is a site, each column a condition, and each cell the number of trials on it — darker means more activity.
Other Trials in Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello
lock Showing 1 of 102 trials — the rest is available on a paid plan.
| Trial | Sponsor | Phase | Status | Start Date | End Date |
|---|---|---|---|---|---|
| A Multicenter, Open-label, Phase 2 Dose Escalation and Confirmation, and Efficacy Expansion Study of Zilovertamab Vedotin (MK-2140) in Combination with R-CHP in Participants with DLBCL (waveLINE) | Merck Sharp & Dohme LLC | Phase II | Not Recruiting | Aug 2022 | — |
IMP list
lock Showing 1 of 178 compounds — the rest is available on a paid plan.
| IMP | Trials | Status | First start | Last start |
|---|---|---|---|---|
| Rituximab | 16 | Unknown | 2017-07-14 | 2025-05-16 |
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