Azienda Ospedaliera Di Perugia

At Azienda Ospedaliera Di Perugia, a major focus is respiratory tract diseases, especially non-small cell lung cancer and small cell lung cancer. The trials are exploring new treatment options, combination strategies, and ways to improve outcomes for people with advanced or resectable disease.

• Advanced and resectable non-small cell lung cancer, including ALK-positive and KRAS G12C-mutated disease
• Extensive-stage small cell lung cancer in patients with limited health status
• Studies aimed at testing new therapies, improving survival, and refining treatment choices before or after surgery

This work reflects a strong clinical interest in better targeted care for lung cancer, with several studies also evaluating treatment effectiveness in difficult-to-treat settings.

The site also supports research in hemic and lymphatic diseases, with trials focused on acute myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia. These studies are designed to assess new anticancer approaches and improve disease control in both newly diagnosed and relapsed settings.

• Acute myeloid leukemia, including cases with NPM1 mutation or MLL rearrangement
• Multiple myeloma in patients eligible for transplant
• Chronic lymphocytic leukemia and small lymphocytic lymphoma after prior treatments

These trials aim to improve response rates, delay progression, and expand options for patients with hard-to-treat blood cancers.

Clinical research at the Department of Pneumology also extends to neoplasms beyond lung cancer, including breast cancer, renal cell carcinoma, hepatocellular carcinoma, and selected solid tumors. The main goal is to evaluate better treatment strategies around surgery and systemic therapy.

• High-risk breast cancer, including hormone receptor-positive disease
• Renal cell carcinoma with metastatic or oligometastatic spread
• Advanced liver cancer and other solid tumors requiring improved treatment control

These trials are examining whether new or personalized approaches can improve long-term outcomes and support more effective cancer care.

The site has an active portfolio in cardiovascular diseases, including atherosclerotic cardiovascular disease, heart failure, and cardiomyopathy. Research is centered on reducing major cardiac events, improving symptom control, and testing therapies for people at elevated cardiovascular risk.

• Heart failure with preserved or mildly reduced ejection fraction, often linked with obesity
• ATTR amyloid cardiomyopathy and related cardiac complications
• Studies aimed at preventing heart attack, stroke, and other serious vascular events

These trials combine prevention and treatment goals, supporting better management of complex heart conditions in everyday clinical practice.

Another important area is immune system diseases, with studies in primary Sjögren's syndrome and transplant-related infections or complications. The research is focused on improving symptom control, reducing inflammation, and supporting safer care after stem cell transplant.

• Primary Sjögren's syndrome and other inflammatory autoimmune conditions
• Cytomegalovirus infection in hematopoietic stem cell transplant recipients
• Trials evaluating new anti-inflammatory or antiviral treatment options

These studies aim to make treatment more effective while also improving tolerability in vulnerable patients.

The trial portfolio includes nutritional and metabolic diseases, particularly obesity and overweight without diabetes. The site is also involved in studies of how body weight, metabolism, and related biological processes affect overall health and treatment response.

• Obesity and overweight management
• Cell physiological phenomena linked to inflammation and disease activity
• Research exploring new ways to support weight reduction and improve metabolic health

These trials are designed to test whether emerging therapies can help reduce cardiovascular and metabolic risk in a practical clinical setting.

Beyond cancer and cardiology, the site also contributes to research in nervous system diseases, virus diseases, and supportive care. Current work includes studies in Alzheimer's disease, electrical storm, and respiratory infection-related conditions.

• Alzheimer's disease and other neurodegenerative conditions
• Electrical storm requiring urgent rhythm control
• Bronchiectasis with chronic bacterial colonization and related infection burden

These projects are aimed at improving diagnosis, symptom control, and treatment effectiveness across a broad range of challenging medical conditions.