ASST Fatebenefratelli Sacco

At ASST Fatebenefratelli Sacco in Milan, a major focus is gastroenterology, especially ulcerative colitis and Crohn’s disease. These studies are exploring new treatment options and better ways to control inflammation, with the goal of improving symptom relief, disease control, and long-term outcomes for people living with inflammatory bowel disease.

• Research in ulcerative colitis and Crohn’s disease
• Studies assessing treatment effectiveness and remission
• Work aimed at improving long-term disease management

The site is also involved in trials looking at more precise treatment strategies for patients with active intestinal disease and related immune-mediated conditions.

This site has a strong portfolio in eye diseases, particularly age-related macular degeneration, diabetic macular edema, uveitis, and other retinal disorders. The trials are designed to evaluate new therapies and improve vision-related outcomes, including approaches that may slow disease progression and preserve sight.

• Age-related macular degeneration and geographic atrophy
• Diabetic macular edema and neovascular eye disease
• Studies of treatments for retinal inflammation and vision loss

Several projects at ASST Fatebenefratelli Sacco are focused on testing ophthalmic treatments that may offer better visual stability and longer-lasting benefit.

Clinical research in cardiovascular diseases includes heart failure, pericarditis, and broader heart-related conditions. These studies are aimed at evaluating treatment effectiveness, reducing worsening events, and supporting better control of chronic and recurrent cardiac inflammation.

• Heart failure and prevention of clinical deterioration
• Recurrent pericarditis and inflammatory heart disease
• Trials focused on improving cardiovascular outcomes

The research also reflects interest in treatments that may help patients with mixed cardiovascular and metabolic risk profiles.

The site contributes to studies in immune system diseases, juvenile idiopathic arthritis, hereditary angioedema, immune thrombocytopenia, and other rare inflammatory conditions. The main aim is to test new therapies, refine disease control, and improve safety and durability of response in patients with complex immune-mediated illness.

• Juvenile idiopathic arthritis and treatment de-escalation strategies
• Hereditary angioedema and acquired angioedema
• Immune thrombocytopenia and autoimmune blood disorders

This area highlights the hospital’s role in advancing care for both common and uncommon immunological diseases.

Another important area is infectious diseases, including COVID-19, sepsis, pneumonia, HIV infection, hepatitis B, and other bacterial or viral infections. These trials are testing new treatments, prevention strategies, and approaches to improve recovery and reduce complications.

• Sepsis and serious hospital-related infections
• Viral infections such as COVID-19, HIV, and hepatitis B
• Studies on infection prevention and recurrence reduction

Research at ASST Fatebenefratelli Sacco also includes work on resistant or difficult-to-treat infections, supporting better antimicrobial care.

Trials in nutritional and metabolic diseases cover type 1 diabetes, type 2 diabetes, obesity, and chronic kidney disease. The purpose of this research is to assess new therapies and care strategies that may improve glucose control, support weight management, and protect kidney function.

• Type 1 diabetes and type 2 diabetes
• Obesity and chronic weight management
• Kidney disease and dialysis-related care

These studies reflect a broad interest in chronic disease management and prevention of long-term complications.

Clinical trials also span nervous system diseases and mental disorders, including epilepsy, schizophrenia, major depressive disorder, obsessive compulsive disorder, and rare neurodevelopmental syndromes. The research is focused on testing new therapies, improving symptom control, and supporting better quality of life across age groups.

• Epilepsy and seizure disorders in children and young adults
• Depression, schizophrenia, and OCD
• Studies in rare neurological and developmental diseases

This therapeutic area shows the site’s involvement in both common psychiatric conditions and highly specialized neurological research.

Additional research includes respiratory tract diseases such as asthma, COPD, and idiopathic pulmonary fibrosis, as well as skin diseases like prurigo nodularis and chronic urticaria. These studies are evaluating new treatment options to reduce symptoms, improve daily functioning, and better manage persistent inflammatory conditions.

• Asthma, COPD, and chronic lung disease
• Prurigo nodularis and chronic spontaneous urticaria
• Trials aimed at symptom relief and disease control

The research portfolio at ASST Fatebenefratelli Sacco also extends to anesthesia, analytical and diagnostic techniques, and other supportive clinical fields.