Amphia Hospital

At Amphia Hospital in Breda, a large share of the research portfolio focuses on neoplasms and blood cancers. Studies cover non-small cell lung cancer, breast cancer, bladder cancer, colorectal cancer, pancreatic cancer, renal cell carcinoma, and a wide range of lymphomas and leukemias. The trials are designed to test new treatment approaches, compare existing options, and improve outcomes such as survival, disease control, and quality of life.

• Targeted and immunotherapy-based studies in advanced solid tumors and metastatic disease
• Research in acute myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, and lymphoma
• Trials seeking better surgical, adjuvant, and combination treatment strategies for cancer care

These oncology studies reflect a broad effort to refine cancer treatment and support more personalized care across both solid and hematologic malignancies.

The site also has strong activity in cardiovascular diseases and metabolic disorders. Research includes acute myocardial infarction, atherosclerotic cardiovascular disease, heart failure, atrial fibrillation, stroke, obesity, and related kidney and inflammation-driven conditions. The main aim is to evaluate therapies that may reduce major cardiovascular events, improve rhythm control, and protect heart and kidney function.

• Prevention of heart attacks, stroke, and other major cardiovascular complications
• Studies in heart failure, atrial fibrillation, and post-infarction care
• Trials addressing obesity, lipid lowering, and broader cardiometabolic risk

This line of research supports better long-term management of common chronic conditions that have a major impact on patient health.

Research in respiratory tract diseases and immune system diseases is another important focus at Amphia Hospital. Trials involve asthma, chronic obstructive pulmonary disease, bronchiectasis, idiopathic pulmonary fibrosis, and pneumonia, alongside immune-driven conditions such as rheumatoid arthritis, multiple sclerosis, lupus, and vasculitis. These studies aim to improve symptom control, reduce flare-ups, and assess more effective and better-tolerated therapies.

• Evaluation of treatments for difficult-to-control asthma and COPD
• Investigations into chronic lung inflammation, infection-related lung disease, and fibrosis
• Immune-focused studies in autoimmune and inflammatory disorders

The research spans both airway disease and systemic immune conditions, reflecting a broad interest in chronic inflammation and its treatment.

The internal medicine research program includes studies in nervous system diseases, especially Alzheimer’s disease, multiple sclerosis, stroke, and intracerebral haemorrhage. These trials are aimed at improving diagnosis, slowing disease progression, and finding more effective ways to manage symptoms and functional decline. Some studies also address early cognitive changes and treatment options for progressive neurological disease.

• Trials in early Alzheimer’s disease and mild cognitive impairment
• Research on multiple sclerosis treatment options and disease control
• Studies focused on recovery and prevention in stroke and brain hemorrhage

This area of research reflects a strong interest in conditions that affect memory, movement, and long-term independence.

Another major theme is research into digestive system diseases, kidney disorders, and urogenital diseases. The trials cover pancreatic cancer, rectal cancer, colitis, Crohn’s disease, ulcerative colitis, acute kidney injury, chronic kidney disease, and multiple bladder and urothelial cancers. The purpose is to improve treatment effectiveness, surgical outcomes, and complication prevention.

• Studies in colorectal and pancreatic cancer to improve survival and recovery
• Research on kidney disease and prevention of acute kidney injury
• Trials in bladder and urothelial cancer exploring better cancer control

These studies show a broad clinical interest in gastrointestinal, renal, and urinary tract health, from inflammatory disease to cancer care.

The site also investigates a diverse set of chronic conditions affecting the skin, hormones, and general health. Research includes hidradenitis suppurativa, vitiligo, atopic dermatitis, psoriasis-related conditions, thyroid disorders, polycystic ovary syndrome, and anemia. These trials generally aim to test new therapies, improve symptom relief, and support better long-term disease management.

• Studies in inflammatory skin disease and pigment disorders
• Research on thyroid and metabolic conditions that affect daily health
• Trials addressing broader quality-of-life outcomes in persistent chronic illness

This part of the portfolio adds breadth to the hospital’s research activity, extending beyond major organ systems to common long-term conditions.