Zuzana Ž.
- Country
- Slovakia
- Department
- 3351: Klinika nefrológie a transplantácií obličiek LF UK a UNB
Research Overview
- Evaluation of Ravulizumab Efficacy and Safety in Adult Patients with Immunoglobulin A Nephropathy: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
- Evaluation of Iptacopan (LNP023) Efficacy and Safety in Complement Inhibitor-Naïve Adult Patients with Atypical Hemolytic Uremic Syndrome
- Phase III Randomized, Double-Blind, Placebo-Controlled Study Evaluating Efficacy and Safety of Iptacopan in Patients with Primary IgA Nephropathy
Data & Insights
Has run more than one trial at 37 of 120 partner sites.
Specializations
Multiple Sclerosis and Neuroimmunology
The investigator is involved in clinical research focused on relapsing multiple sclerosis, primary progressive multiple sclerosis, and secondary progressive multiple sclerosis, with interest in therapies that address inflammatory activity, relapse prevention, and long-term disease control.
- Relapsing multiple sclerosis
- Primary progressive multiple sclerosis
- Ocrelizumab and ofatumumab
- Remibrutinib and tolebrutinib
Research activity also extends to neurodegenerative burden in multiple sclerosis and treatment options for motor fluctuations in Parkinson's disease.
Cardiovascular, Stroke, and Heart Failure
Clinical work includes prevention and treatment strategies for atherosclerotic cardiovascular disease, high cardiovascular risk, heart failure, and ischemic stroke, with attention to vascular protection and event reduction.
- Primary prevention of atherosclerotic cardiovascular disease
- Heart failure with kidney impairment
- Prevention of ischemic stroke
- Inclisiran, asundexian, and balcinrenone/dapagliflozin
The therapeutic landscape also includes hypertension, chronic heart failure, and post-event vascular risk management.
Ophthalmology and Retinal Disease
The investigator is active in trials addressing neovascular age-related macular degeneration, diabetic macular edema, retinal vein occlusion, and diabetic retinopathy, reflecting a strong focus on vision-threatening retinal disorders.
- Neovascular age-related macular degeneration
- Diabetic macular edema
- Diabetic retinopathy
- Thyroid eye disease
Additional interest is seen in aflibercept-based retinal therapy and treatments for optic and orbital inflammation.
Kidney and Complement-Mediated Disorders
Research involvement includes IgA nephropathy, chronic kidney disease, atypical hemolytic uremic syndrome, and other renal conditions where immune and complement pathways are therapeutically relevant.
- IgA nephropathy
- Chronic kidney disease
- Atypical hemolytic uremic syndrome
- Proteinuria and eGFR preservation
The portfolio also includes studies in primary focal segmental glomerulosclerosis and minimal change disease.
Inflammatory, Respiratory, and Oncology Domains
The investigator also participates in trials across bullous pemphigoid, alopecia areata, hidradenitis suppurativa, moderate-to-severe COPD, COVID-19, and selected solid and hematologic malignancies.
- Bullous pemphigoid and alopecia areata
- Moderate-to-severe COPD and COVID-19
- Non-small cell lung cancer
- Chronic myeloid leukemia and multiple myeloma
Other areas include NASH, migraine, refractory status epilepticus, and cognitive disorders linked to Alzheimer’s disease.
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