Željko Č.
- Country
- Croatia
- Department
- NA
Research Overview
- A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Tulisokibart in Participants with Moderately to Severely Active Ulcerative Colitis
- Phase 3 Randomized Double-Blind Placebo-Controlled Study of Tulisokibart Efficacy and Safety in Moderately to Severely Active Crohn's Disease
- Efficacy and Safety of RO7790121 Induction Therapy in Moderately to Severely Active Crohn's Disease: A Phase III, Multicenter, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 169 of 301 partner sites.
Specializations
Inflammatory Bowel Disease
Clinical research activity includes Crohn’s disease, ulcerative colitis, and broader gastrointestinal inflammation, reflecting a strong therapeutic focus within gastroenterology and hepatology.
- Crohn’s disease
- Ulcerative colitis
- Moderate to severe active intestinal inflammation
The research landscape also includes therapies aimed at controlling mucosal inflammation and maintaining long-term disease control in chronic immune-mediated bowel disease.
Autoimmune and Inflammatory Disorders
Investigator involvement extends across systemic autoimmune disease and inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus, Sjögren’s syndrome, and dermatomyositis.
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Sjögren’s syndrome
This area also covers IgA nephropathy and focal segmental glomerulosclerosis, linking immune dysregulation with renal disease management.
Dermatology and Immune-Mediated Skin Disease
Research interests include atopic dermatitis, alopecia areata, and psoriatic arthritis, with attention to chronic inflammatory skin disease and related quality-of-life burden.
- Atopic dermatitis
- Alopecia areata
- Severe inflammatory skin disease
The therapeutic focus includes immune-targeted approaches for persistent dermatologic inflammation in both pediatric and adult populations.
Neurology and Neuropsychiatric Disease
Clinical trial involvement spans multiple sclerosis, focal-onset seizures, primary generalized tonic-clonic seizures, alzheimer’s disease, mild cognitive impairment, psychosis associated with Alzheimer’s disease, agitation in dementia, and bipolar I disorder.
- Multiple sclerosis
- Alzheimer’s disease
- Epilepsy
This portfolio also includes research in major depressive disorder and tardive dyskinesia, indicating a broad interest in neurological and psychiatric symptom control.
Cardiometabolic and Cardiovascular Medicine
Additional research activity covers atrial fibrillation, cardiovascular disease, primary prevention of atherosclerotic cardiovascular disease, hypertension, and type 2 diabetes, alongside outcomes relevant to thromboembolic and heart-failure risk.
- Atrial fibrillation
- Cardiovascular disease
- Type 2 diabetes
The therapeutic scope includes risk reduction strategies for vascular disease and metabolic comorbidity in patients with chronic inflammatory disorders.
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