ZAHER L.
- Country
- France
- Department
- Chirurgie générale, digestive et cancérologique
Research Overview
- Pragmatic Randomized Trial of Patient‑Driven Choice (Oral Amoxicillin/Clavulanic Acid vs Appendectomy) vs Systematic Appendectomy in Uncomplicated Acute Appendicitis
- Phase III Randomized Trial of Neoadjuvant Chemotherapy and Pelvic Reirradiation Versus Chemotherapy Alone in Locally Recurrent Rectal Cancer
- Phase III Randomized Trial of Preoperative Chemotherapy vs. Chemotherapy Plus Chemoradiotherapy in Locally Advanced Resectable Rectal Carcinoma
Data & Insights
Has run more than one trial at 36 of 74 partner sites.
Specializations
Digestive Oncology
Clinical trial activity in digestive cancer focuses on resectable and advanced malignancies of the colon, rectum, stomach, pancreas, biliary tract, and esophagus, with additional interest in neuroendocrine tumors and complex postoperative settings.
- Colorectal cancer
- Pancreatic adenocarcinoma
- Gastric and gastroesophageal junction cancer
- Hepatocellular carcinoma
- Esophageal carcinoma
Work in this area also includes surgical oncology for digestive tumors, with attention to treatment strategies for locally advanced, metastatic, and recurrent disease.
Breast and Gynecologic Cancer
The investigator is involved in studies on breast cancer across early, locally advanced, and metastatic settings, including hormone receptor-positive, HER2-negative, HER2-low, and triple-negative disease, as well as endometrial, ovarian, cervical, and uterine sarcoma malignancies.
- Hormone receptor-positive breast cancer
- Triple-negative breast cancer
- Endometrial cancer
- Ovarian cancer
- Cervical cancer
Therapeutic interests extend to biomarker-defined disease, postoperative risk reduction, and management of recurrent or unresectable gynecologic cancers.
Thoracic and Head and Neck Oncology
Research involvement includes non-small cell lung cancer, small cell lung cancer, and head and neck squamous cell carcinoma, with coverage of resected, locally advanced, and metastatic presentations.
- Non-small cell lung cancer
- Small cell lung cancer
- Head and neck squamous cell carcinoma
- Melanoma
- Cutaneous squamous cell carcinoma
The clinical focus also includes melanoma and other skin cancers, reflecting interest in advanced solid tumors requiring systemic and perioperative treatment approaches.
Urologic and Renal Malignancies
Investigational activity covers prostate cancer, renal cell carcinoma, and urothelial carcinoma, with attention to localized, recurrent, and metastatic disease states.
- Prostate cancer
- Renal cell carcinoma
- Urothelial carcinoma
- Bladder cancer
- Kidney cancer
These studies also address high-risk disease biology and treatment optimization in genitourinary oncology.
Hematology, Immunology, and Supportive Care
The investigator participates in trials spanning acute leukemia, lymphoma, myelodysplastic syndromes, and multiple myeloma, alongside immune-mediated disorders such as Crohn's disease, ulcerative colitis, rheumatoid arthritis, and multiple sclerosis.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Inflammatory bowel disease
- Cardiovascular disease
Additional research interests include cardiovascular prevention, stroke, thrombosis, and postoperative complications, linking oncologic care with broader internal medicine and perioperative support.
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