Zagorka P.
- Country
- France
- Department
- Chirurgie orthopédique et traumatologie pédiatrique
Research Overview
Data & Insights
Has run more than one trial at 0 of 4 partner sites.
Specializations
Pediatric Orthopedic and Skeletal Growth Disorders
Focused on congenital and acquired conditions affecting the musculoskeletal system of children, with an emphasis on surgical correction and disease-modifying therapies.
- Achondroplasia
- Hypochondroplasia
- Osteogenesis Imperfecta
- Congenital pseudarthrosis of the tibia
- Generalized arterial calcification of infancy
Research integrates orthopedic surgery with emerging biologic interventions to improve bone integrity and growth outcomes.
Rare Genetic and Metabolic Kidney Diseases
Investigation of inherited renal disorders and metabolic pathways that lead to chronic kidney injury, aiming to preserve renal function and delay progression.
- Alport syndrome
- Autosomal Dominant Polycystic Kidney Disease
- Primary Hyperoxaluria
- Nephrotic syndrome associated with FSGS
- Immunoglobulin A Nephropathy
Efforts include genotype‑guided therapeutic strategies and supportive care for pediatric patients.
Hematologic, Immunologic, and Bone Marrow Disorders
Targeted studies on blood‑cell abnormalities, immune dysregulation, and marrow failure syndromes prevalent in the pediatric population.
- Duchenne Muscular Dystrophy
- Severe hemophilia A and B
- Wiskott‑Aldrich syndrome
- X‑linked chronic granulomatous disease
- Auto‑inflammatory diseases (e.g., NLRC4‑GOF)
Collaborations span gene‑therapy, enzyme replacement, and immune‑modulating approaches.
Transplantation, Graft Function, and Post‑Transplant Complications
Clinical focus on kidney and hematopoietic stem cell transplantation, emphasizing graft survival, sensitization management, and microangiopathic complications.
- Highly sensitised kidney transplant recipients
- HSCT‑associated thrombotic microangiopathy
- Delayed graft function in deceased donor kidneys
- Post‑transplant lymphoproliferative disorder
- Adolescent renal allograft outcomes
Research integrates immunologic profiling with innovative desensitization and prophylactic regimens.
Vascular, Neurologic, and Inflammatory Pediatric Conditions
Exploration of diseases affecting cerebral vasculature, neurodevelopment, and systemic inflammation in children.
- Focal cerebral arteriopathy
- Diffuse intrinsic pontine glioma
- Juvenile idiopathic arthritis subtypes
- Behçet’s disease with oral ulcers
- Inflammatory bowel disease (Crohn’s disease, ulcerative colitis)
Efforts aim to define pathophysiologic mechanisms and test targeted anti‑inflammatory therapies.
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