Yann N.
- Country
- France
- Department
- Urology
Research Overview
- SUrGery with or without dARolutamide in high-risk and/or locally advanced prostate cancer
- Perioperative Durvalumab plus Cisplatin-Based Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer: A Global Open-Label Single-Arm Study
- Phase 2 Open‑Label Single‑Arm Study of Enfortumab Vedotin Plus Pembrolizumab for Bladder Preservation in Patients with Muscle‑Invasive Bladder Cancer
Data & Insights
Has run more than one trial at 80 of 256 partner sites.
Specializations
Urologic Oncology
The clinical research profile includes a strong focus on prostate cancer, bladder cancer, and renal cell carcinoma, with interest in both localized and metastatic disease. The portfolio also extends to urothelial carcinoma and other advanced genitourinary malignancies.
- Metastatic castration-resistant prostate cancer
- High-risk non-muscle invasive bladder cancer
- Metastatic renal cell carcinoma
- Locally advanced or metastatic urothelial cancer
Research activity reflects involvement in treatment strategies for recurrence prevention, disease control, and therapeutic sequencing in genitourinary oncology.
Thoracic Malignancies
Another major area of interest is non-small cell lung cancer, including advanced, metastatic, and biomarker-defined subtypes. The research scope also includes small cell lung cancer and resectable disease in the adjuvant setting.
- Advanced non-small cell lung cancer
- EGFR exon 20 insertion–positive lung cancer
- ROS1-positive lung cancer
- Small cell lung cancer
Therapeutic interest is centered on immunotherapy, targeted therapy, and combination approaches in lung cancer.
Neurology and Neurovascular Disease
The investigator is also involved in studies spanning multiple sclerosis, ischemic stroke, intracerebral haemorrhage, and glioblastoma. This includes both acute neurologic care and long-term disease-modifying strategies.
- Relapsing and secondary progressive multiple sclerosis
- Acute ischemic stroke
- Intracerebral haemorrhage
- Glioblastoma
Research activity covers neuroinflammation, stroke prevention, and treatment development in malignant brain tumors.
Autoimmune, Inflammatory, and Transplant Medicine
Clinical interests include giant cell arteritis, sarcoidosis, asthma, and several immune-mediated disorders, alongside transplant rejection and kidney-related immune disease. The portfolio also touches on systemic vasculitis and pulmonary inflammatory conditions.
- Giant cell arteritis
- Severe asthma
- Sarcoidosis
- Kidney transplant rejection
Therapeutic domains include immunomodulation, corticosteroid-sparing treatment, and management of autoimmune vasculitis.
Infectious Disease and Critical Care
The trial landscape also includes HIV, community-acquired pneumonia, hospital-acquired bacterial pneumonia, septic shock, and nontuberculous mycobacterial lung infection. These studies reflect interest in severe infection management and antimicrobial strategies.
- Primary HIV-1 infection
- Hospital-acquired bacterial pneumonia
- Septic shock
- Nontuberculous mycobacterial lung infection
Research activity spans antimicrobial therapy, critical care infection, and prevention of infectious complications.
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